Emerging themes in bacterial autophagy.

Emerging themes in bacterial autophagy.
Curr Opin Microbiol. 2014 Dec 9;23C:163-170
Authors: Sorbara MT, Girardin SE
Abstract
The role of autophagy in the control of intracellular bacterial pathogens, also known as xenophagy, is well documented. Here, we highlight recent advances in the field of xenophagy. We review the importance of bacterial targeting by ubiquitination, diacylglycerol (DAG) or proteins such as Nod1, Nod2, NDP52, p62, NBR1, optineurin, LRSAM1 and parkin in the process of xenophagy. The importance of metabolic sensors, such as mTOR and AMPK, in xenophagy induction is also discussed. We also review the in vitro and in vivo evidence that demonstrate a global role for xenophagy in the control of bacterial growth. Finally, the mechanisms evolved by bacteria to escape xenophagy are presented.
PMID: 25497773 [PubMed - as supplied by publisher]

Source: Current Opinion in Microbiology - December 9, 2014 Category: Microbiology Authors: Sorbara MT, Girardin SE Tags: Curr Opin Microbiol Source Type: research