LC-MS/MS Analysis of Puerarin and 18 β-Glycyrrhetinic acid in Human Plasma After Oral Administration of Samso-eum and its Application to Pharmacokinetic Study.

In this study, a liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS) method was validated for the simultaneous determination of puerarin and 18β-glycyrrhetinic acid in human plasma. This was the first study to evaluate pharmacokinetics of puerarin and 18β-glycyrrhetinic acid after usual oral dose of Samso-eum (30 g containing 102.48 mg puerarin, 48.18 mg glycyrrhizin) in human subjects. PMID: 31813157 [PubMed - as supplied by publisher]
Source: Biomedical Chromatography : BMC - Category: Biomedical Science Authors: Tags: Biomed Chromatogr Source Type: research