The interplay among Th17 and T regulatory cells in the immune dysregulation of chronic dermatophytic infection

Publication date: Available online 10 December 2019Source: Microbial PathogenesisAuthor(s): Gargi Rai, Shukla Das, Mohammad Ahmad Ansari, Praveen Kumar Singh, Deepika Pandhi, Richa Anjleen Tigga, Sambit Nath Bhattacharya, Chhavi Gupta, Sajad Ahmad DarAbstractThe delineation of the pathogenic interaction between the host skin immune responses and dermatophytes has remained indigent. The obscure enigma in host-dermatophyte immunopathogenic interactions is the T regulatory (Treg) and T-helper (Th) 17  cell role in maintaining immune homeostasis. We attempted to understand the regulation and recognition of lineage-specific response in chronic dermatophytic skin infection patients. The percentages of Th17 (CD4+CD161+IL23R+) and Treg (CD4+CD25+FoxP3+) cell subpopulations in the peripheral circulation of thirty chronic dermatophytic skin infection patients and twenty healthy individuals was determined. The serum cytokine levels were estimated for disease co-relation. The mean duration of the disease was 10.68 ± 8.72 months, with Trichophyton mentagrophyte complex as the major pathogen. Total serum IgE level of patients was significantly higher compared to healthy controls (305 ± 117 vs 98.53 ± 54.55 IU/ml; p < 0.01). Expression of Th17 and Treg cell markers on CD4+ T cells was significantly elevated in patients than controls (p < 0.05). Comparatively, serum interleukin (IL)-4 and interferon (IFN)-γ levels were increased, with low IL-10 levels in pat...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research