Relative difference in muscle strength between patients with knee osteoarthritis and healthy controls when tested bilaterally and joint-inclusive: an exploratory cross-sectional study

To improve the goal-directedness of strength exercises for patients with knee osteoarthritis (KOA), physical rehabilitation specialists need to know which muscle-groups are most substantially weakened across t...
Source: BMC Musculoskeletal Disorders - Category: Orthopaedics Authors: Tags: Research article Source Type: research

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Authors: Schmitz MR, Murtha AS, Clohisy JC, ANCHOR Study Group Abstract Developmental dysplasia of the hip (DDH) in adolescents and young adults can cause notable pain and dysfunction and is a leading cause of progressive hip osteoarthritis in affected patients. Recognition of the clinical symptoms and radiographic presentation of DDH in adolescents and young adults are paramount for early management. Plain radiographs are critical for making proper diagnosis, whereas three-dimensional imaging including MRI and/or CT detects intra-articular pathology and better characterizes hip morphology. Management of early, sym...
Source: The Journal of the American Academy of Orthopaedic Surgeons - Category: Orthopaedics Tags: J Am Acad Orthop Surg Source Type: research
This study aims to identify the prevalence of preoperative opioid prescriptions and the specialty and practice setting of the prescriber, as well as the percentage of patients who do not report their opioid prescriptions and any variables associated with preoperative opioid prescriptions. METHODS: A total of 461 consecutive new patients evaluated for an arthritic hip or knee were retrospectively studied using institutional data from a tertiary-care, urban center at a university-affiliated private-practice and the state Prescription Monitoring Program to identify opioid prescriptions (including medication, number of pil...
Source: The Journal of the American Academy of Orthopaedic Surgeons - Category: Orthopaedics Tags: J Am Acad Orthop Surg Source Type: research
Publication date: Available online 25 January 2020Source: Journal of OrthopaedicsAuthor(s): Yoshinori Ishii, Hideo Noguchi, Junko Sato, Hana Ishii, Ryo Ishii, Shin-ichi ToyabeAbstractBackgroundProlonged operative time has frequently been implicated as a risk factor for various complications after total knee arthroplasty (TKA). We aimed to determine whether preoperative factors such as sex, age, body mass index (BMI), prosthetic design, tibiofemoral angle (TFA), range of motion, coronal laxity, Hospital for Special Surgery score and periarticular bone mineral density (BMD) affect operative time.MethodsWe evaluated 164 patie...
Source: Journal of Orthopaedics - Category: Orthopaedics Source Type: research
Source: BMJ Comments - Category: General Medicine Source Type: forums
CONCLUSIONS The present study demonstrated that 2-aminoquinoline prevents articular cartilage damage in osteoarthritis rats through inhibition of inflammatory factors and downregulation of NF-kappaB activation, suggesting that 2-aminoquinoline would be effective in treatment of osteoarthritis. PMID: 31978040 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
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Source: Lippincott's Bone and Joint Newsletter - Category: Orthopaedics Tags: Perspective Source Type: news
Objectives: To compare clinical and functional outcomes of total elbow arthroplasty (TEA) for distal humerus fractures (DHF) performed either as a primary procedure or after internal fixation. Design: Retrospective, observational study. Setting: Mayo Clinic, Rochester, MN (1998 through 2016). Patients/Participants: Twenty-two TEA for acute DHF and 66 TEA after previous internal fixation. Main Outcome Measurements: Primary outcome measures included the Mayo Elbow Performance Score and motion. Reoperation rates and complications were also compared. Results: The mean time between internal fixation and arthrop...
Source: Journal of Orthopaedic Trauma - Category: Orthopaedics Tags: Original Article Source Type: research
This study examined baseline gait differences between progression and no progression groups defined at an average of 7-year follow-up using 2 different outcomes indicative of knee osteoarthritis progression: radiographic medial joint space narrowing and total knee arthroplasty. Of 49 individuals with knee osteoarthritis who underwent baseline gait analysis, 32 progressed and 17 did not progress using the radiographic outcome, while 13 progressed and 36 did not progress using the arthroplasty outcome. Key knee moment and electromyography waveform features were extracted using principal component analysis, and confidence int...
Source: Journal of Applied Biomechanics - Category: Sports Medicine Tags: J Appl Biomech Source Type: research
AbstractNF ‐κB is known to be implicated in skeletal development and related diseases. Previous studies have shown that RelA, a key subunit of NF‐κB, is involved in osteoblast and chondrocyte survival and differentiation. Yet, the physiological roles of RelA in mesenchymal stem cells (MSCs), which give r ise to both chondrocytes and osteoblasts, are still poorly understood. Here, we generatedPrrx1 ‐Cre;RelAf/f mice to deleteRelA in Prrx1+ bone marrow MSCs and found thatRelA deletion led to decreased MSC proliferation and altered differentiation, with increased osteogenic and chondrogenic differentiation b...
Source: FEBS Letters - Category: Biochemistry Authors: Tags: RESEARCH ARTICLE Source Type: research
Conclusion:These data suggest that hNCs-3D are valuable therapeutic agents for repair and regeneration of cartilage defects.
Source: Tissue Engineering and Regenerative Medicine - Category: Biotechnology Source Type: research
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