Prognostic value of dual-point fluorine-18 fluorodeoxyglucose PET imaging, partial volume correction and glucose transporter-1 expression in resected nonsmall cell lung cancer patients.

Objective To investigate the relationship between the prognosis and glucose transporter-1 (Glut-1) expression or fluorine-18 fluorodeoxyglucose uptake using partial volume correction and dual-point imaging in surgically resected nonsmall cell lung cancer (NSCLC) patients. Methods Our patient population consisted of 108 NSCLC cases. The early maximum standardized uptake value (ESUVmax), delayed SUVmax (DSUVmax), partial volume correction SUVmax (cSUVmax) and retention index of primary lesions were calculated. Cox proportional hazard model was applied to evaluate the effects of PET parameters and Glut-1 expression. Overall survival (OS) and disease-free survival (DFS) were evaluated by Kaplan–Meier methods, and the difference in survival between subgroups was analyzed by log-rank test. Results On the Cox regression analysis, ESUVmax, DSUVmax, cSUVmax and Glut-1 were significantly related to DFS [ESUVmax, hazard ratio  = 2.301, 95% confidential interval (CI) = 1.146–4.618, P = 0.019; DSUVmax, hazard ratio = 2.483, 95% CI = 1.257–4.905, P = 0.009; cSUVmax, hazard ratio = 2.205, 95% CI = 1.038–4.686, P = 0.04; Glut-1, hazard ratio = 2.095, 95% CI = 1.086–4.041, P = 0.001] and OS (ESUVmax, hazard ratio = 3.197, 95% CI = 1.339–7.633, P = 0.009; DSUVmax, hazard ratio = 3.599, 95% CI = 1.521–8.516, P = 0.004; cSUVmax, hazard ratio = 8.655, 95% CI = 2.048–36.658, P = 0.003; Glut-1...
Source: Nuclear Medicine Communications - Category: Nuclear Medicine Tags: Original Articles Source Type: research