Governments must make tackling AMR worth pharmacy's while
Pharmaceutical companies won ’t develop fast, cheap and effective diagnostic tools on their own — they need incentives to tackle antimicrobial resistance.
Infections are common in terminally ill patients (PTS), and although antibiotics are frequently prescribed, their benefit for symptom relief is not clear. Antimicrobials at the end of life (EOL) increase the risk of antimicrobial resistance and Clostridium difficile infection. Very few studies have described the risks and benefits of antimicrobials in PTS at EOL. Here, we describe a retrospective chart review of antimicrobial use at EOL.
Wastewater treatment plants (WWTPs) are considered hotspots for the environmental dissemination of antimicrobial resistance (AMR) determinants. Vancomycin-Resistant Enterococcus (VRE) are candidates for gauging t...
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Publication date: Available online 22 January 2020Source: International Journal of PharmaceuticsAuthor(s): Sara García-Salinas, Michael Evangelopoulos, Enrique Gámez-Herrera, Manuel Arruebo, Silvia Irusta, Francesca Taraballi, Gracia Mendoza, Ennio TasciottiAbstractWound healing is a complex process that consists of three overlapping phases: inflammation, proliferation, and remodeling. A bacterial infection can increase inflammation and delay this process. Microorganisms are closely related to the innate immune system, such as macrophages and neutrophils, as they can start an inflammatory cascade. Essential o...
Two reports from the World Health Organisation highlight concern over the lack of investment. It is stated that the 60 products in development (50 antibiotics and 10 biologics) bring little benefit over existing treatments and very few target gram-negative bacteria.
Antimicrobial resistance is an increasing problem in hospitals world-wide. Following other countries, English hospitals experienced outbreaks of carbapenemase-producing Enterobacteriaceae (CPE), a bacterial infection commonly resistant to last resort antibiotics. One way to improve CPE prevention, management and control is the production of guidelines, such as the CPE toolkit published by Public Health England in December 2013. The aim of this research was to investigate the implementation of the CPE toolkit and to identify barriers and facilitators to inform future policies.
AbstractIntroductionSurgical site infections (SSIs) are among the most common healthcare-associated infections. They are associated with longer post-operative hospital stays, additional surgical procedures, risk of treatment in intensive care units and higher mortality.Material and methodsSSIs were detected in patients hospitalized in a 40-bed orthopaedics ward in 2009 –2018. The total number of study patients was 15,678. The results were divided into two 5-year periods before and after the introduction of the SSI prevention plan. The study was conducted as part of a national Healthcare-Associated Infections Su...
ConclusionTo our knowledge, this is the first study that reports the widespread expansion of multidrug resistance amongUreaplasma serovars, a finding of importance in terms of both surveillance and antimicrobial usage.
ConclusionThis is the first report showing the high prevalence of carbapenemases in ESBL-positive isolates in this area. Regular surveillance for such resistance mechanisms will be useful for health personnel to treat infections by these multidrug-resistant pathogens.
[Ghanaian Times] There is concern about the effects of irrational use of antibiotics. This is not only because of the issue of antimicrobial resistance but importantly about the effect of antibiotics on the gut microbiota. The digestive tract especially the large intestine is the habitat for millions of microbes living in concert with several functions of the body. Antibiotics have been very useful in treating and controlling infections with positive impact of standard of living.