Rv2223c, an acid inducible carboxyl-esterase of Mycobacterium tuberculosis enhanced the growth and survival of Mycobacterium smegmatis

Future Microbiology, Ahead of Print.
Source: Future Microbiology - Category: Microbiology Authors: Source Type: research

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Publication date: Available online 29 January 2020Source: IDCasesAuthor(s): Syuichi Tetsuka, Tomohiro Suzuki, Tomoko Ogawa, Ritsuo Hashimoto, Hiroyuki KatoAbstractThe aging phenomenon of tuberculosis (TB) patients is recognized all over the world, but no country is as prominent as Japan. Central nervous system (CNS) TB includes clinical entities: tuberculous meningitis, intracranial tuberculoma, and clinical features of CNS TB in the elderly may be atypical, non-specific, and confused with concomitant age-related diseases. Atypical clinical manifestations of TB in older persons can result in delay in diagnosis and initiati...
Source: IDCases - Category: Infectious Diseases Source Type: research
Publication date: Available online 29 January 2020Source: IDCasesAuthor(s): Junichiro Kawagoe, Yuki Maeda, Goro Kawamata, Nobuyuki Koyama, Hiroyuki Nakamura, Kazutetsu Aoshiba
Source: IDCases - Category: Infectious Diseases Source Type: research
Publication date: Available online 27 January 2020Source: Saudi Journal of Biological SciencesAuthor(s): Ameer Khusro, Chirom Aarti, B. Mahizhaveni, Azger Dusthackeer, Paul Agastian, Galal Ali Esmail, Abdul-Kareem Mohammed Ghilan, Naif Abdullah Al-Dhabi, Mariadhas Valan ArasuAbstractThe present context was investigated to purify and characterize anti-tubercular as well as anticancer protein from fermented food associated Staphylococcus hominis strain MANF2. Initially, the anti-tubercular potency of strain MANF2 was assessed against Mycobacterium tuberculosis H37Rv using luciferase reporter phase assay which revealed pronou...
Source: Saudi Journal of Biological Sciences - Category: Biology Source Type: research
Publication date: Available online 27 January 2020Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Romina P. Martinelli, Julia M. Rodriguez, Lucas D. Daurelio, Luis EstebanAbstractRenal and extrarenal production of the active form of vitamin D, 1,25-dihydroxyvitamin D (1,25(OH)2D), is catalyzed by CYP27B1, an enzyme also called 1-α-hydroxylase. The overproduction of 1,25(OH)2D has been described in granulomatous diseases. High circulating concentrations of 1,25(OH)2D can lead to hypercalcemia. The aim of this work was to characterize the transcriptional regulation of CYP27B1 in human mononu...
Source: The Journal of Steroid Biochemistry and Molecular Biology - Category: Biochemistry Source Type: research
ConclusionCryobiopsy is easier and more efficient than biopsy with conventional forceps. Our findings in these patients suggest that semi-rigid thoracoscopic cryobiopsy might be a useful alternative diagnostic method for undiagnosed pleural effusion in elderly patients.
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
ConclusionsTB can have varied presentation and therefore it is essential to keep tubercular infection in differential diagnosis while working up for any infective pathology. Conservative treatment produces good results in vast majority of cases. Surgery is reserved for select indications.
Source: Journal of Clinical Orthopaedics and Trauma - Category: Orthopaedics Source Type: research
Publication date: Available online 27 January 2020Source: Current Medicine Research and PracticeAuthor(s): K.K. Chopra, Shweta SinghAbstractTB has remained a disease of Public Health Importance since ages affecting more than 10 million people globally and taking lives of 2 million people worldwide people every year. Despite of the dramatic improvements made in providing high-quality TB diagnostic services, since the discovery of the causative bacilli, many people with TB remain undiagnosed or get diagnose only after long delays. Ten countries account for 77% of this gap and use only smear microscopy for diagnosis, which fo...
Source: Current Medicine Research and Practice - Category: General Medicine Source Type: research
[ANGOP] Luanda -The chairperson of the Global Fund, Donald Kaberuka, reaffirmed this Monday, in Luanda, his support to the Angolan Government, with the aim of eradicating diseases such as malaria, tuberculosis and HIV / AIDS, by 2030.
Source: AllAfrica News: Malaria - Category: Infectious Diseases Source Type: news
(Boston Children's Hospital) New research from the Precision Vaccines Program at Boston Children's Hospital shows that BCG vaccines for tuberculosis prevention vary widely in their ability to activate components of the immune system. These findings highlight important differences between BCG formulations and the need for a large clinical study comparing them.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
We report the case of a 28-year-old male patient with end-stage renal disease who presented with long-standing systemic symptoms and genitourinary manifestations, who was diagnosed with urogenital tuberculosis both by clinical and microbiologic criteria. Clinicians should always suspect tuberculosis in patients with chronic symptoms, especially in those with immunosuppression.
Source: Revista da Sociedade Brasileira de Medicina Tropical - Category: Tropical Medicine Source Type: research
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