Effects of Physical Activity and Sedentary Behavior on Histological Risk Factors of Carotid Atherosclerotic Plaque Instability

Introduction - Carotid atherosclerosis plaque instability is increased by intraplaque hemorrhage (IPH) neovascularization and inflammation (1). Oxidative stress is known to promote these three risk factors and induce a vicious circle with IPH and neovascularization (2). Moreover, it was shown that regular physical activity can reduce oxidative stress by increasing antioxidant defenses whereas sedentary behavior can increase oxidative stress independently to physical activity (3, 4). The aim of this study was therefore to evaluate the effects of both physical activity and sedentary behavior on the carotid plaque histological characteristics and oxidative stress in patients at high-risk of stroke.

Source: European Journal of Vascular and Endovascular Surgery - November 30, 2019 Category: Surgery Authors: Pauline Mury, Virginie Nicaise, Mathilde Mura, Vincent Pialoux, Antoine Millon Source Type: research