Rotavirus Vaccination: 5 Things to Know Rotavirus Vaccination: 5 Things to Know
With rotavirus vaccination rates lagging behind those of other childhood vaccines, many children still suffer from severe rotavirus disease. Here are five things to know.CDC Expert Commentary
Condition: Rotavirus Gastroenteritis Interventions: Biological: Rotavirus RV3 Vaccine (Bio Farma); Other: Placebo Sponsor: PT Bio Farma Not yet recruiting
Conclusions: Our review highlights similarities and differences in the application of the test-negative design that deserve further examination. If vaccination reduces disease severity in breakthrough infections, particular care must be taken in interpreting vaccine effectiveness estimates from test-negative design studies.
This study examined the RV vaccine effectiveness against risk of hospitalization based on a retrospective cohort study and the impact of public expense for the RV vaccine on this regional RV gastroenteritis epidemic. The vaccination coverage was significantly higher in children in Shari and Koshimizu than in Abashiri (87.8% vs. 42.7%, respectively, p
Human group A rotavirus is the leading cause of severe acute gastroenteritis in young children worldwide. Immunization programs have reduced the disease burden in many countries. Vaccination coverage in the Au...
Conclusions: The present study found RVA positivity in 30.62% of children with gastroenteritis, with the highest burden among 24–36 months old. The predominant genotypes were G1, G3, and P. Further large-scale/multicentric studies should be conducted to document the diversity of circulating RVA genotypes in this region for giving inputs for vaccination strategy.
Authors: Kotsopoulos N, Haitsma G, Connolly MP, Standaert B Abstract Background: The economics of rotavirus gastroenteritis in infants
CONCLUSIONS: Even though the evidence shows a DS-1-like change trend, data from studies conducted in Latin America and the Caribbean are diverse and still not sufficient to assess the impact of vaccines on viral ecology or if genetic diversity is influenced by natural mechanisms of fluctuation. PMID: 31771863 [PubMed - as supplied by publisher]
Conclusions: Enteropathogen infections were common around the time of rotavirus vaccination in rural Zimbabwean infants but did not explain poor RVV immunogenicity and were not reduced by a package of household-level WASH interventions.
Conclusion RV5 is well tolerated in premature infants and does not result in clinically significant adverse events when administered in NICU-hospitalized infants. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents | Abstract | Full text