Rotavirus Vaccination: 5 Things to Know Rotavirus Vaccination: 5 Things to Know

With rotavirus vaccination rates lagging behind those of other childhood vaccines, many children still suffer from severe rotavirus disease. Here are five things to know.CDC Expert Commentary
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Pediatrics Commentary Source Type: news

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(Children's Hospital Los Angeles) The rotavirus vaccine--which protects against diarrhea and resulting dehydration-- is less effective in children in middle- and low-income countries. Investigators will use genomics to optimize effectiveness of the vaccine in order to decrease hospitalizations and deaths in young children worldwide.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
From 2016, the Government of India introduced the oral rotavirus vaccine into the national immunization schedule. Currently, two indigenously developed vaccines (ROTAVAC, Bharat Biotech; ROTASIIL, Serum Instit...
Source: BMC Infectious Diseases - Category: Infectious Diseases Authors: Tags: Research article Source Type: research
ConclusionThe current RotaBIS data show a maintained reduction, around 76%, in RV hospitalization cases. Simulations show that these results could have been improved to an import extent with a more optimal initiation of the vaccination program.Trial registrationClinicalTrials.gov identifier, NCT01563146 and NCT01563159.
Source: Infectious Diseases and Therapy - Category: Infectious Diseases Source Type: research
Novel computational tools for swine vaccine development can expand the range of immunization approaches available to prevent economically devastating swine diseases and spillover events between pigs and humans. PigMatrix and EpiCC are two new tools for swine T cell epitope identification and vaccine efficacy analysis that have been integrated into an existing computational vaccine design platform named iVAX. The iVAX platform is already in use for the development of human vaccines, thus integration of these tools into iVAX improves and expands the utility of the platform overall by making previously validated immunoinforma...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
We present a case of a 27-month-old girl who was hospitalized for 4 days with severe gastroenteritis, including high fever, vomiting, diarrhea, mild dehydration, and periumbilical pain. Notably, the patient previously received the Rotarix vaccine. Diagnoses: The laboratory tests were negative for rotavirus, astrovirus, adenovirus, and norovirus as well as common diarrhea-causing bacteria. Human-bovine recombinant rotavirus was detected by MinION sequencing. Interventions: To investigate the cause agents from the unexplained severe gastroenteritis infant, the stool sample was prepared by random amplification for Nanop...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
by Michael B. Arndt, Jason L. Cantera, Laina D. Mercer, Michael Kalnoky, Heather N. White, Gregory Bizilj, David S. Boyle, Eugenio L. de Hostos, Robert K. M. Choy Environmental enteric dysfunction (EED) is an intestinal disorder common among children in low-resource settings and is associated with increased risk of growth stunting, cognitive deficits, and reduced oral vaccine immunogenicity. The Micronutrient and EED Assessment Tool (MEEDAT) is a multiplexe d immunoassay that measures biomarkers previously associated with child growth faltering and/or oral vaccine immunogenicity: intestinal fatty acid–binding protei...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
ro JJ Abstract PURPOSE: Although quantitative benefit-risk models (qBRms) are indisputably valuable tools for gaining comprehensive assessments of health care interventions, they are not systematically used, probably because they lack an integrated framework that provides methodologic structure and harmonization. An alternative that allows all stakeholders to design operational models starting from a standardized framework was recently developed: the discretely integrated condition event (DICE) simulation. The aim of the present work was to assess the feasibility of implementing a qBRm in DICE, using the example o...
Source: Clinical Therapeutics - Category: Drugs & Pharmacology Authors: Tags: Clin Ther Source Type: research
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Source: Human Vaccines and Immunotherapeutics - Category: Allergy & Immunology Authors: Source Type: research
Conclusion: A considerable economic burden is faced by the families for treating diarrhea in under-five children. Improved access to safe drinking water and sanitation, promotion of hand hygiene, exclusive breastfeeding, rotavirus vaccination, and use of oral rehydration therapy will reduce hospitalization and out-of-pocket expenditure. The study findings recommend for appropriate policy for provision of financial protection while seeking health care services.
Source: Indian Journal of Public Health - Category: International Medicine & Public Health Authors: Source Type: research
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Source: Human Vaccines and Immunotherapeutics - Category: Allergy & Immunology Authors: Source Type: research
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