Breast Cancer Vaccines: Heeding the Lessons of the Past to Guide a Path Forward

Cancer vaccines represent an active immunotherapy designed to stimulate the patient ’s immune system to recognize and kill tumor cells. Optimally, cancer vaccines stimulate type 1 CD4+ and CD8+T cell responses against tumor-associated antigens (Ags) (TAAs) and/or tumor specific Ags (TSAs) [1,2]. The main classes of TAAs and TSAs are summarized in Table 1. Known tumor Ags relevant to BC are shown in Table 2.

Source: Cancer Treatment Reviews - November 28, 2019 Category: Cancer & Oncology Authors: Cinzia Solinas, Marco Aiello, Edoardo Migliori, Karen Willard-Gallo, Leisha A. Emens Tags: Tumour Review Source Type: research