Exosome-derived microRNA-22 ameliorates pulmonary fibrosis by regulating fibroblast-to-myofibroblast differentiation both in vitro and in vivo.

ConclusionsExosomal miR-22 modulates fibroblast-to-myofibroblast differentiation. The present study warrants further investigations to shed light on miR-22 as a novel therapeutic target for patients with IPF.
PMID: 31776321 [PubMed - as supplied by publisher]

Source: Journal of Nippon Medical School - November 27, 2019 Category: Universities & Medical Training Authors: Kuse N, Kamio K, Azuma A, Matsuda K, Inomata M, Usuki J, Morinaga A, Tanaka T, Kashiwada T, Atsumi K, Hayashi H, Saito Y, Seike M, Gemma A Tags: J Nippon Med Sch Source Type: research