Structural characterization, hepatoprotective and antihyperlipidemic activities of alkaloid derivatives from Murraya koenigii

Publication date: February 2020Source: Phytochemistry Letters, Volume 35Author(s): Rongrui Wei, Qinge Ma, Guoyue Zhong, Yulun Su, Jianbo Yang, Aiguo Wang, Tengfei Ji, Hongxia Guo, Meiling Wang, Ping Jiang, Haichao WuAbstractThree new alkaloids (1-3) and a new natural alkaloid (4), named (1′R,3′R,4′R,6′S)-endocycliomurrayamine-A (1), 3-formyle-7-hydroxy-9H-carbazole-1-O-β-d-glucopyranoside (2), 4′-hydroxyphenyl-6-ethyl-1H-pyrrole-2-carboxaldehyde (3), and 4-hydroxyphenoxy-N-methyl-propanamide (4), together with thirteen known alkaloid derivatives (5–17) were isolated from Murraya koenigii. Among them, compounds (8–17) were isolated from this plant for the first time. The structures of compounds (1–17) were elucidated on the basis of their spectroscopic analysis and references. Compounds 1, 15, 16, and 17 (10 μM) showed moderate hepatoprotective activities against d-galactosamine-induced HL-7702 cells damage. Compounds 2, 3, 9, and 13 showed moderate activation of PPARα and PPARγ receptors.Graphical abstract

Source: Phytochemistry Letters - November 29, 2019 Category: Chemistry Source Type: research