X-chromosome genetic association test incorporating X-chromosome inactivation and imprinting effects.

X-chromosome genetic association test incorporating X-chromosome inactivation and imprinting effects.
J Genet. 2019 Nov;98:
Authors: Liu W, Wang BQ, Liu-Fu G, Fung WK, Zhou JY
Abstract
Studies have shown that many complex diseases are sex-determined. When conducting genetic association studies on X-chromosome, there are two important epigenetic factors which should be considered simultaneously: X-chromosome inactivation and genomic imprinting. Currently, there have been several association tests accounting for the information on X-chromosome inactivation. However, these tests do not take the imprinting effects into account. In this paper, we propose a novel association test simultaneously incorporating X-chromosome inactivation and imprinting effects based on case-parent trios and control-parent trios for female offspring and case-control data for male offspring, denoted by MLRXCII. Extensive simulation studies are carried out to investigate the type I error rate and the test power of the proposed MLRXCII . Simulation results demonstrate that the proposed test controls the type I error rate well andis more powerful than the existing method when imprinting effects exist. The proposed MLRXCII test is valid and powerful in genetic association studies on X-chromosome for qualitative traits and thus is recommended in practice.
PMID: 31767819 [PubMed - in process]

Source: Journal of Genetics - October 31, 2019 Category: Genetics & Stem Cells Authors: Liu W, Wang BQ, Liu-Fu G, Fung WK, Zhou JY Tags: J Genet Source Type: research