Anal Cancer Rates, Deaths Are Climbing, Study Finds
You are leaving AARP.org and going to the website of our trusted provider. ... The provider ’s terms, conditions and policies apply. ... Please return to AARP.org to learn more about other benefits.
The expert spoke about ongoing trials of novel treatment strategies that may lead to the development of new therapies in this space.
ConclusionWe present a real-world experience of shifting radiation technique from conventional 3D-CRT to IMRT. IMRT patients had better tumor control at 1 year and lower degrees of skin toxicity. Our data indicate that IMRT can enable therapies with lower side effects with equal or better oncological results for patien ts with ACa.
The incidence of anal cancer is rising in the last decades and more women are affected than men. The prognosis after chemoradiation is very good with complete remission rates of 80 –90%. Thus, reducing therapy-...
CONCLUSIONS: Consistent with its design, CUE-101 demonstrates selective expansion of an HPV16 E711-20-specific population of cytotoxic CD8+T cells, a favorable safety profile, and in vitro and in vivo evidence supporting its potential for clinical efficacy in an ongoing Phase 1 trial (NCT03978689). PMID: 31964784 [PubMed - as supplied by publisher]
Conditions: Anal Cancer; Anal Carcinoma; Anal Cancer Stage III; Anal Cancer Stage II Interventions: Drug: Chemotherapy; Radiation: Radiation; Drug: Durvalumab Sponsor: Goethe University Recruiting
AbstractPurpose of ReviewWith advances in radiation therapy (RT) techniques for rectal and anal cancers allowing for the modulation of critical normal tissues, there has been an increased emphasis on improving the quality of life (QOL) for cancer survivors. Herein, we review the literature to examine the impact of RT on QOL and patient-reported outcomes (PROs) to better inform providers about the challenges of survivorship.Recent FindingsLarge systematic reviews, recent studies, and long-term follow-up of pivotal clinical trials have shown that RT impacts QOL, particularly fecal continence and sexual function. Modern preop...
Conditions: Anal Cancer; Anal Carcinoma; Anal Cancer Stage III; Anal Cancer Stage II Interventions: Drug: Chemotherapy; Radiation: Radiation; Drug: PD-L1 Sponsor: Goethe University Recruiting
British Journal of Cancer, Published online: 14 January 2020; doi:10.1038/s41416-019-0690-4Whither Anal Cancer?
British Journal of Cancer, Published online: 14 January 2020; doi:10.1038/s41416-019-0689-xTemporal improvements in loco-regional failure and survival in patients with anal cancer treated with chemo-radiotherapy: treatment cohort study (1990–2014)