Anal Cancer Rates, Deaths Are Climbing, Study Finds

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Source: AARP.org News - Category: American Health Source Type: news

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The expert spoke about ongoing trials of novel treatment strategies that may lead to the development of new therapies in this space.
Source: CancerNetwork - Category: Cancer & Oncology Authors: Source Type: news
ConclusionWe present a  real-world experience of shifting radiation technique from conventional 3D-CRT to IMRT. IMRT patients had better tumor control at 1 year and lower degrees of skin toxicity. Our data indicate that IMRT can enable therapies with lower side effects with equal or better oncological results for patien ts with ACa.
Source: Strahlentherapie und Onkologie - Category: Cancer & Oncology Source Type: research
The incidence of anal cancer is rising in the last decades and more women are affected than men. The prognosis after chemoradiation is very good with complete remission rates of 80 –90%. Thus, reducing therapy-...
Source: BMC Cancer - Category: Cancer & Oncology Authors: Tags: Study protocol Source Type: research
CONCLUSIONS: Consistent with its design, CUE-101 demonstrates selective expansion of an HPV16 E711-20-specific population of cytotoxic CD8+T cells, a favorable safety profile, and in vitro and in vivo evidence supporting its potential for clinical efficacy in an ongoing Phase 1 trial (NCT03978689). PMID: 31964784 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - Category: Cancer & Oncology Authors: Tags: Clin Cancer Res Source Type: research
Conditions:   Anal Cancer;   Anal Carcinoma;   Anal Cancer Stage III;   Anal Cancer Stage II Interventions:   Drug: Chemotherapy;   Radiation: Radiation;   Drug: Durvalumab Sponsor:   Goethe University Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
AbstractPurpose of ReviewWith advances in radiation therapy (RT) techniques for rectal and anal cancers allowing for the modulation of critical normal tissues, there has been an increased emphasis on improving the quality of life (QOL) for cancer survivors. Herein, we review the literature to examine the impact of RT on QOL and patient-reported outcomes (PROs) to better inform providers about the challenges of survivorship.Recent FindingsLarge systematic reviews, recent studies, and long-term follow-up of pivotal clinical trials have shown that RT impacts QOL, particularly fecal continence and sexual function. Modern preop...
Source: Current Colorectal Cancer Reports - Category: Cancer & Oncology Source Type: research
Conditions:   Anal Cancer;   Anal Carcinoma;   Anal Cancer Stage III;   Anal Cancer Stage II Interventions:   Drug: Chemotherapy;   Radiation: Radiation;   Drug: PD-L1 Sponsor:   Goethe University Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
British Journal of Cancer, Published online: 14 January 2020; doi:10.1038/s41416-019-0690-4Whither Anal Cancer?
Source: British Journal of Cancer - Category: Cancer & Oncology Authors: Source Type: research
British Journal of Cancer, Published online: 14 January 2020; doi:10.1038/s41416-019-0689-xTemporal improvements in loco-regional failure and survival in patients with anal cancer treated with chemo-radiotherapy: treatment cohort study (1990–2014)
Source: British Journal of Cancer - Category: Cancer & Oncology Authors: Source Type: research
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