Nonbullous Pemphigoid Unrecognized Cause of Pruritus in Nursing Homes Nonbullous Pemphigoid Unrecognized Cause of Pruritus in Nursing Homes

Nonbullous pemphigoid can be more frequent among nursing home residents than bullous pemphigoid and may be an unrecognized cause of pruritus, a cross-sectional study suggests.Reuters Health Information
Source: Medscape Allergy Headlines - Category: Allergy & Immunology Tags: Dermatology News Source Type: news

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Many autoimmune skin diseases, such as bullous pemphigoid (BP), psoriasis and certain types of chronic urticaria, are associated with intensive pruritus. While histamine and neuropeptides have previously been ascribed to play a role in itch that accompanies these diseases, recent evidence suggests that the pruritogenic cytokine interleukin (IL)-31 is a major driver of pruritic responses. IL-31 was originally shown to be produced by activated helper T cells, particularly Th2 cells, mast cells, macrophages and dendritic cells. However, more recent evidence demonstrated that eosinophils are a major source of this cytokine too...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
We present a case of PCG in a 13 year old female patient which clinically presented as generalized desquamative gingivitis involving the facial aspects of the attached and marginal gingiva that persisted despite substituting to a non flavored dentifrice and failure to elicit any suspected drug or food allergies. Dermatologic patch testing proved positive for Iodopropynyl Butylcarbamate (IPBC), a water based preservative or biocide used in personal care products. Microscopically, there was an intense inflammatory infiltrate in the lamina propria composed predominantly of mature plasma cells. Immunohistochemistry and in situ...
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
Conclusions The clinical trials discussed here, which include several trials investigating novel therapeutic targets, demonstrate that translational research in pemphigus and pemphigoid is a fast-growing field. We thus expect that several novel treatments will be shortly available for the treatment of pemphigus and pemphigoid patients. Given the high, and thus far unmet, medical need in this field (110), this is highly encouraging and will hopefully improve the quality of life of the affected patients. In addition to the compounds and targets described here, several new targets have been recently identified in preclinical...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Which patients are at risk of developing this skin condition?Medscape Dermatology
Source: Medscape Allergy Headlines - Category: Allergy & Immunology Tags: Dermatology Viewpoint Source Type: news
Mucous Membrane Pemphigoid is a rare and debilitating disease that affects bodily mucous membranes, especially those of the eyes and oropharynx. It results in ocular surface disease leading to scarring, lid abnormalities and vision loss. Hypertrichosis associated with increased local prostaglandin levels due to topical medication or other types of ocular inflammation has been well documented. We hypothesize that mucous membrane pemphigoid also increases local prostaglandin levels and this increased concentration of prostaglandin contributes to an enhanced lash growth rate.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research
We report this case because it describes a rare clinical entity, with an atypical clinical presentation pemphigoid-like, that is rarely described in literature. PMID: 27152606 [PubMed - indexed for MEDLINE]
Source: European Annals of Allergy and Clinical Immunology - Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research
Mucosal membrane pemphigoid (MMP) is an autoimmune disorder characterized by subepithelial blisters associated with mucous membranes such as those of the oral cavity, conjunctiva, and larynx. The report described a case of MMP in a patient allergic to corticosteroids. A 75-year-old woman complained of “painful blisters on the gingiva” with 8 months of evolution. An intraoral physical examination revealed ulceration in the lower gingiva near tooth 43. The patient reported to a follow-up with an ophthalmologist and allergy to corticosteroids.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - Category: ENT & OMF Authors: Tags: Oral and Maxillofacial Pathology Source Type: research
Publication date: July–August 2018Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 6, Issue 4Author(s): Mark D.P. Davis, Jeroen C.H. van der HilstA wide differential diagnosis must be considered in a patient presenting with urticarial plaques. Although acute and chronic urticaria are the commonest diagnoses, other differential diagnoses include polymorphous eruption of pregnancy, mast cell disorders, hypereosinophilic syndrome, urticarial vasculitis, pemphigoid, systemic lupus erythematosus, and autoinflammatory disease. This review will specifically address urticarial vasculitis and autoin...
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
Provide a brief overview of the clinical presentation, common offending agents, management, prognosis, and mortality of selected six high-risk drug rashes, namely Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), drug reaction with eosinophilia and systemic symptoms (DRESS), multiple drug hypersensitivity syndrome (MDH), acute generalized exanthematous pustulosis (AGEP), and drug-induced bullous pemphigoid (DIBP).
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Review Articles Source Type: research
CONCLUSION: In such high-risk drug rashes, early recognition, immediate withdrawal of the suspected drug(s), prompt individualized management, and monitoring vital organs function are mandatory for reducing morbidity and mortality. The lack of reliable tests for identification of the causative agent imposes difficulty, particularly in patients receiving multiple medications. PMID: 29803714 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Ann Allergy Asthma Immunol Source Type: research
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