Influence of Foetal Macrosomia on the Neonatal and Maternal Birth Outcome.

The objective of this study is the generation of descriptive data on the mode of delivery and on maternal and foetal complications in the case of foetal macrosomia. The causes and consequences of foetal macrosomia as well as the rate of shoulder dystocia are examined in relation to the severity of the macrosomia. Patients The study investigated all singleton births ≥ 37 + 0 weeks of pregnancy with a birth weight ≥ 4000 g at the Charité University Medicine Berlin (Campus Mitte 2001 - 2017, Campus Virchow Klinikum 2014 - 2017). Results 2277 consecutive newborns (birth weight 4000 - 4499 g [88%], 4500 - 4999 g [11%], ≥ 5000 g [1%]) were included. Maternal obesity and gestational diabetes were more common in the case of newborns weighing ≥ 4500 g than newborns weighing 4000 - 4499 g (p = 0.001 and p 
Source: Geburtshilfe und Frauenheilkunde - Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

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This study aimed to evaluate the reproducibility of three BIA instruments in pregnancy and analyse the relationship between the body composition and the GDM risk. Methods: A prospective cohort (n = 117) of women with singleton pregnancies participating in the Microbiome Understanding in Maternity Study (MUMS) at St. George Hospital, Sydney, Australia. Anthropometric measurements and BIA body composition were measured at ≤13 weeks (T1), 20-24 weeks (T2), and 32-36 weeks (T3) of gestation. Body fat percentage (BFP), total body water (TBW), and impedance were estimated by three BIA instruments: Bodystat 1...
Source: Journal of Obesity - Category: Eating Disorders & Weight Management Tags: J Obes Source Type: research
Background and objective: The maternal glucose-insulin axis is central for metabolic adaptations required for a healthy pregnancy. Metabolic changes in obese mothers in early pregnancy have been scantly described. Here we characterized the glucose-insulin axis in the first trimester of human pregnancy and assessed the effect of maternal obesity and fat mass.Methods: In this cross-sectional study, maternal blood samples (N = 323) were collected during voluntary pregnancy termination (gestational age 4+0–11+6 weeks) after overnight fasting. Smokers (N = 198) were identified by self-report and serum cotinine levels (ELI...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Conditions:   Weight Loss;   Gestational Diabetes Interventions:   Other: PAIGE2 lifestyle intervention;   Other: Standard care Sponsors:   Belfast Health and Social Care Trust;   Northern Health and Social Care Trust;   South Eastern Health and Social Care Trust;   Interreg;   Our Lady of Lourdes Hospital, Drogheda;   Sligo General Hospital;   Letterkenny University Hospital Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Positive pregnancy and birthing experiences go beyond merely having a healthy mother and baby — so, too, does maternal justice, a term that encompasses broad goals. Affordable, timely, high-quality, equitable, and dignified care during and after pregnancy is essential for all birthing people. Maternal justice is a model of culturally sensitive care that aims to dismantle inequities in maternity care and maximize maternal health and well-being. It rests on human rights and requires us to chip away at racism entrenched in health systems. How do race and ethnicity affect pregnancy and birth? Globally, Black, indigenous,...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Adolescent health Health care disparities Parenting Pregnancy Women's Health Source Type: blogs
Authors: Šimják P, Anderlová K, Cinkajzlová A, Pařízek A, Kršek M, Haluzík M Abstract Gestational diabetes mellitus (GDM) is diabetes that is first diagnosed in the second or third trimester of pregnancy in patients who did not have a history of diabetes before pregnancy. Consequences of GDM include increased risk of macrosomia and birth complications in the infant and an increased risk of maternal type 2 diabetes mellitus (T2DM) after pregnancy. There is also a longer-term risk of obesity, T2DM, and cardiovascular diseases in the child. GDM is the result of impaire...
Source: Minerva Endocrinologica - Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
ConclusionsWomen in our study with pre-gestational diabetes were overweight, were older and had long-standing diabetes mellitus. Our patients with type 2 diabetes had a higher BMI, were older, had a shorter duration of diabetes mellitus and had better diabetes control compared to women with type 1 diabetes. Women treated with continuous subcutaneous insulin infusion had a higher rate of miscarriage with more congenital malformations. The initial inadequate diabetes control was significantly improved during pregnancy.
Source: Diabetes Therapy - Category: Endocrinology Source Type: research
The impact of female abnormalities of body mass index (BMI) and its association with subfertility and increased time to pregnancy (TTP) have been well-characterized (1). This may be due to the impact of BMI on ovulatory status in women, though TTP is increased even among women with a high BMI and reportedly regular cycles (2). Patients with higher BMIs, those in the overweight and obese categories, are at increased risk for gestational issues including gestational diabetes, hypertension, and difficulty with fetal monitoring.
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Reflections Source Type: research
Authors: Qiu J, Liu Y, Zhu W, Zhang C Abstract BACKGROUND Women with normal fasting glucose (FPG) range (5.1 ≤FPG
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Haslam Collins Self-administered eHealth interventions provide a potential low-cost solution for reducing diabetes risk. The aim of this pilot randomised controlled trial (RCT) was to evaluate the feasibility, including recruitment, retention, preliminary efficacy (primary outcome) and acceptability (secondary outcome) of the “Body Balance Beyond” eHealth intervention in women with previous gestational diabetes mellitus (GDM). Women with overweight/obesity who had recent GDM (previous 24 months) were randomised into one of three groups: 1) high personalisation (access to “Body Balance ...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
In conclusion, it remains unclear if brain-specific regional and temporal changes occur in the expression of the different APP variants during AD progression. Since APP is also found in blood cells, assessing the changes in APP mRNA expression in peripheral blood cells from AD patients has been considering an alternative. However, again the quantification of APP mRNA in peripheral blood cells has generated controversial results. Brain APP protein has been analyzed in only a few studies, probably as it is difficult to interpret the complex pattern of APP variants and fragments. We previously characterized the soluabl...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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