The Efficacy and Safety of Esketamine for the Treatment-Resistant Depression in Older Adults: Comments on TRANSFORM-3 Trial Results.

The Efficacy and Safety of Esketamine for the Treatment-Resistant Depression in Older Adults: Comments on TRANSFORM-3 Trial Results. Am J Geriatr Psychiatry. 2019 Oct 18;: Authors: Lavretsky H, Roose SP PMID: 31734082 [PubMed - as supplied by publisher]
Source: The American Journal of Geriatric Psychiatry - Category: Psychiatry Tags: Am J Geriatr Psychiatry Source Type: research

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ConclusionsThe findings highlight the acceptability of physical activity as a mental health intervention tool within a post-secondary context. Importantly the results provide implications for developing strategies to incorporate physical activity as an acceptable support method within mental health services.
Source: Mental Health and Physical Activity - Category: Psychiatry & Psychology Source Type: research
Conclusions: Our data are in accordance with previous findings outlining that N + insomniacs have higher PSQI scores than N-. Our results do not confirm the suggested association between napping and depressive or obsessive-compulsive symptoms. Conversely, we found a statistically significant difference (p = 0.0014) in EAT scores in N + and N-. Hyperarousal and REM sleep instability in insomniac patients may create an unbalance of the neuroendocrine hypothalamic regulation leading to an appetite alteration. PMID: 31790624 [PubMed - as supplied by publisher]
Source: Nordic Journal of Psychiatry - Category: Psychiatry Tags: Nord J Psychiatry Source Type: research
Hyperactivity of the hypothalamic-pituitary-adrenal axis and impairment of the central corticotropin-releasing factor system are factors in the pathogenesis of depression. Though several antagonists of the corticotropin-releasing factor 1 receptor were effective in the recognized behavioral tests for antidepressant activity, there is still little information on the potential interactions between corticotropin-releasing factor 1 receptor inhibitors and conventional antidepressant therapy. The aim of our study was to assess the influence of CP154526, a corticotropin-releasing factor 1 receptor blocker, which presented some s...
Source: NeuroReport - Category: Neurology Tags: Degeneration and Repair Source Type: research
The long noncoding RNA, steroid receptor RNA activator (SRA), has been reported to be involved in the development of many types of disease in humans. The aim of this study was to evaluate whether SRA was associated with poststroke depression (PSD). A PSD rat model was established, and depression-like behaviors and sucrose consumption in rats with PSD were analyzed. Reverse transcription-quantitative PCR (RT-PCR), western blot and luciferase dual reporter assay analyses were performed to detect the expression of peroxisome proliferator-activated receptor γ (PPARγ) expression following SRA small interfering RNA (...
Source: NeuroReport - Category: Neurology Tags: Degeneration and Repair Source Type: research
Sports-related concussion in youth is tied to a marked increased risk for subsequent suicide risk factors, including depression, suicidal ideation, and suicide attempts, new research shows.Medscape Medical News
Source: Medscape Neurology and Neurosurgery Headlines - Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news
One of the biotech industry ’s emerging neuroscience companies, Sage Therapeutics, disclosed Thursday that one of its most promising potential products failed a late-stage study. The Cambridge-company's shares fell by more than half on Thursday morning, shaving more than $3 billion off its market value. Sage (Nasdaq: SAGE) has become one of the area biotech industry’s most closely watched companies through its work on postpartum depression and other psychiatric disorders. It has consistently…
Source: Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news
Publication date: Available online 4 December 2019Source: Computers in Human BehaviorAuthor(s): Jörg Matthes, Kathrin Karsay, Desirée Schmuck, Anja StevicAbstractMobile social networking sites (SNS) are frequently theorized to lead to perceived information overload, which may affect the well-being of individuals in negative ways. However, the available body of research is mainly based on cross-sectional data. Based on the limited capacity model of motivated mediated message processing (Lang, 2002), we tested the over-time relationships between mobile SNS use, information overload, depressive symptoms, and well-...
Source: Computers in Human Behavior - Category: Information Technology Source Type: research
Publication date: Available online 4 December 2019Source: Air Medical JournalAuthor(s): Minh Le Cong, Susan Markwell, Liza RobertsonAbstractAeromedical retrieval of acutely suicidal pregnant patient can be facilitated by novel use of ketamine and it's rapid antidepressant property.
Source: Air Medical Journal - Category: Emergency Medicine Source Type: research
Sage Therapeutics Inc's experimental drug for severe depression failed a closely-watched study, setting up the drugmaker to lose about $4.5 billion in valuation when the market opens.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
We all love and look forward to the holidays, but even good things can be stressful.  Listen in as our guest,’s founder, Dr. John Grohol, tells us how to avoid overindulging this year, how to handle the extra work burdens of the season, and how to deal with that annoying relative. SUBSCRIBE &REVIEW Guest information for ‘Holiday Coping’ Podcast Episode John M. Grohol, Psy.D. is a pioneer in online mental health and psychology. Recognizing the educational and social potential of the Internet in 1995, Dr. Grohol has transformed the way people could access mental health and psyc...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Family General Holiday Coping Interview LifeHelper Podcast Relationships Stress The Psych Central Show Source Type: blogs
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