Immune-Mediated Colitis

AbstractPurpose of reviewThis review addresses our current knowledge of immune-mediated colitis (IMC) and offers a practical guide to its management.Recent findingsDue to the similarity in clinical, endoscopic, and histologic findings between IMC and inflammatory bowel disease (IBD), gastroenterologists have tailored their approach to IMC management to that of IBD.SummaryImmune checkpoint inhibitors (ICIs) are monoclonal antibodies that augment the T-cell anti-tumor response of the immune system and have demonstrated their importance in the treatment of a wide range of malignancies. With the growing benefits of ICIs, there are immune-related adverse events (irAEs) that mirror many known autoimmune diseases. Diarrhea and IMC are the most common and severe irAEs noted. No standardized guidelines exist in the management of these irAEs.
Source: Current Treatment Options in Gastroenterology - Category: Gastroenterology Source Type: research