Rhythmicity matters: Circadian and ultradian patterns of HPA axis activity

Publication date: Available online 15 November 2019Source: Molecular and Cellular EndocrinologyAuthor(s): Caroline M.B. Focke, Karl J. IremongerAbstractOscillations are a fundamental feature of neural and endocrine systems. The hypothalamic-pituitary-adrenal (HPA) axis dynamically controls corticosteroid secretion in basal conditions and in response to stress. Across the 24-h day, HPA axis activity oscillates with both an ultradian and circadian rhythm. These rhythms have been shown to be important for regulating metabolism, inflammation, mood, cognition and stress responsiveness. Here we will discuss the neural and endocrine mechanisms driving these rhythms, the physiological importance of these rhythms and health consequences when they are disrupted.
Source: Molecular and Cellular Endocrinology - Category: Endocrinology Source Type: research