T cell polarization differs in various stages of discoid lupus erythematosus skin.

T cell polarization differs in various stages of discoid lupus erythematosus skin. Br J Dermatol. 2019 Nov 13;: Authors: Coias J, Marzuka A, Hosler GA, Chong BF Abstract The clinical presentation and pathology of discoid lupus erythematosus (DLE) varies by stage. Erythematous scaly papules and plaques characterize the early lesions. They progress to dyspigmented patches and plaques with central scarring and atrophy. Under histology, early lesions demonstrate a perivascular and perifollicular inflammatory infiltrate, liquefactive degeneration and keratinocyte apoptosis. Increased collagen deposition within the dermis and reduced inflammatory infiltrate is seen in later stages [1]. PMID: 31721152 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - Category: Dermatology Authors: Tags: Br J Dermatol Source Type: research