Plasmapharesis in Patients with Heparin-Induced Thrombocytopenia Requiring Ventricular Assist Device.

We describe two patients with HIT confirmed via serotonin release assay who were successfully treated with plasmapheresis exchange before LVAD placement. PMID: 31715152 [PubMed - as supplied by publisher]
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Ann Thorac Surg Source Type: research

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CONCLUSION: Correction of the adverse events was made either using causal treatment or using symptomatic drugs. However, some drugs, in particular hematopoietic factors, have been less used due to their costs.
. PMID: 32101521 [PubMed - as supplied by publisher]
Source: International Journal of Clinical Pharmacology and Therapeutics - Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research
Publication date: Available online 25 February 2020Source: The Annals of Thoracic SurgeryAuthor(s): Federica Jiritano, Roberto Lorusso, Giuseppe Santarpino
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
This study aimed to compare the efficacy and safety of traditional Chinese medicines (TCMs) combined with paclitaxel-based chemotherapy and paclitaxel-based chemotherapy alone for gastric cancer treatment. Literature searches (up to September 25, 2019) were performed using the Cochrane Library, EMBASE, PubMed, Chinese Science and Technology Journals (CQVIP), Wanfang, and China Academic Journals (CNKI) databases. Data from 14 randomized controlled trials (RCTs), with 1,109 participants, were included. The results indicated that, compared with paclitaxel-based chemotherapy alone, the combination of TCMs and paclitaxel-based ...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
This study evaluated the haematological profile of adult individuals infected with the malaria parasite. Methods: A retrospective study was conducted using archived data of malaria positive cases from January 2017 to March 15, 2019. Data retrieved included subjects' demographics, malaria parasite count, malaria parasite species, and full blood count parameters. A total of 236 malaria positive subjects were included in the study. Results: The study showed that more females were infected with the malaria parasite than males (69.07% and 30.93%, respectively). A total of 87.3% of the study population were infected with...
Source: Advances in Hematology - Category: Hematology Tags: Adv Hematol Source Type: research
Authors: Le Marec J, Henique H, Rubenstein E, Bigot A, Puyade M, Urbanski G, Lozac'h P, Allain JS, Bayer G, Fain O, Lioger B PMID: 32089036 [PubMed - as supplied by publisher]
Source: Platelets - Category: Hematology Tags: Platelets Source Type: research
Publication date: Available online 25 February 2020Source: Journal of BiotechnologyAuthor(s): Ján Miertuš, Paolo Enrico Maltese, Michaela Hýblová, Erika Tomková, Darina Ďurovčíková, Vanda Rísová, Matteo Bertelli
Source: Journal of Biotechnology - Category: Biotechnology Source Type: research
In conclusion, romiplostim dosing, effectiveness and safety in these unselected ITP patients seemed comparable with observations in clinical trials and similarly designed observational studies.
Source: Memo - Magazine of European Medical Oncology - Category: Cancer & Oncology Source Type: research
ConclusionsThe efficacy and tolerability profiles of T-DM1 are generally favorable compared with other treatments for unresectable or metastatic HER2-positive BC.
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
Publication date: Available online 22 February 2020Source: Pharmacology &TherapeuticsAuthor(s): Kimiyasu Shiraki, Tohru DaikokuAbstractFavipiravir has been developed as an anti-influenza drug and licensed as an anti-influenza drug in Japan. Additionally, favipiravir is being stockpiled for 2 million people as a countermeasure for novel influenza strains. This drug functions as a chain terminator at the site of incorporation of the viral RNA and reduces the viral load. Favipiravir cures all mice in a lethal influenza infection model, while oseltamivir fails to cure the animals. Thus, favipiravir contributes to curing an...
Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research
Shiga toxin (Stx)-producing Escherichia coli (STEC) is the main cause of postdiarrheal hemolytic-uremic syndrome (HUS), a life-threatening clinical complication characterized by hemolytic anemia, thrombocytopenia, and acute renal failure that mainly affects children. A relevant feature of STEC strains is the production of Stx, and all of them express Stx1 and/or Stx2 regardless of the strain serotype. Therefore, Stx detection assays are considered the most suitable methods for the early detection of STEC infections. Single-domain antibodies from camelids (VHHs) exhibit several advantages in comparison with conventional ant...
Source: Journal of Clinical Microbiology - Category: Microbiology Authors: Tags: Immunoassays Source Type: research
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