Cl- as a bona fide signalling ion.

Cl- as a bona fide signalling ion.
Am J Physiol Cell Physiol. 2019 Nov 06;:
Authors: Lüscher BP, Vachel L, Ohana E, Muallem S
Abstract
Cl- is the major extracellular (Cl-out) and intracellular (Cl-in) anion whose concentration is actively regulated by multiple transporters. These transporters generate Cl- gradients across the plasma membrane and between the cytoplasm and intracellular organelles. [Cl-]in changes rapidly in response to cell stimulation and influences many physiological functions as well as cellular and systemic homeostasis. However, less appreciated is the signaling function of Cl-. Cl- interacts with multiple proteins to directly modify their activity. This review highlights the signaling function of Cl- and argues that Cl- is a bona fide signaling ion, a function deserving extensive exploration.
PMID: 31693396 [PubMed - as supplied by publisher]

Source: Am J Physiol Cell Ph... - November 5, 2019 Category: Cytology Authors: Lüscher BP, Vachel L, Ohana E, Muallem S Tags: Am J Physiol Cell Physiol Source Type: research