Cervical spinal instability causes vertebral microarchitecture change and vertebral endplate lesion in rats

ConclusionsSpinal instability induced by CMS increases bone mass and biomechanical loading of the ventral side of vertebrae in the early stage, which might initiate VEP damage and cause intervertebral disc degeneration.The translational potential of this articleOur study indicates that vertebral trabecular changes may involve in intervertebral disc degeneration induced by spinal instability. This may help to elucidate the mechanisms by which disc degeneration occur.

Source: Journal of Orthopaedic Translation - November 7, 2019 Category: Orthopaedics Source Type: research