Cyclosporine May Be an Option in Allergic ConjunctivitisCyclosporine May Be an Option in Allergic Conjunctivitis

Topical cyclosporine may spare patients the adverse effects associated with corticosteroids, investigators say. Medscape Medical News
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Ophthalmology News Source Type: news

Related Links:

Date: June 1, 2020 Issue #:  1599Summary:  A 0.24% ophthalmic solution of the second-generation H1-antihistamine cetirizine (Zerviate– Eyevance) is now available by prescription for treatment of ocular itching associated with allergic conjunctivitis in patients ≥2 years old. Oral cetirizine (Zyrtec, and others), which is used for treatment of allergic conjunctivitis and rhinitis, has been available over the counter (OTC) for years.
Source: The Medical Letter - Category: Drugs & Pharmacology Authors: Tags: Acular Alaway Alcaftadine Allergic rhinitis Alocril Alomide nedocromil Antihistamines azelastine Bepotastine Bepreve cetirizine Clear Eyes Conjunctivitis corticosteroids Cromolyn Epinastine Ketorolac Ketotifen Lastacaft Source Type: research
Abstract Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by relapsing eczema and pruritus. Until the development of Dupilumab, a new monoclonal antibody targeting IL-4 and IL-13 receptors, the current treatment of severe cases was based on immunosuppressant agents. Our main goal was to build a case series of five patients with severe atopic dermatitis, who were using immunosuppressive drugs with significant adverse effects and only partially controlled AD, and compare their symptoms, SCORAD index, treatment regimens, total and specific IgE, and blood cell count before and after the intr...
Source: Allergologia et Immunopathologia - Category: Allergy & Immunology Authors: Tags: Allergol Immunopathol (Madr) Source Type: research
Authors: Kudsieh B, Sánchez-Dehesa Sáez M, Flores Moreno I, Ruiz Moreno JM Abstract CLINICAL CASE: A 16-year-old patient seen in the Emergency Department due to loss of visual acuity (VA) in the left eye (LE), and oppressive headache of 1 day onset. The patient was on treatment with topical corticosteroids for viral conjunctivitis. The VA was 1.00 in the right eye and 0.05 in LE. The intraocular pressure was 42mmHg in both eyes. In the LE, the funduscopy revealed retinal ischaemic oedema in the papillomacular bundle. The optical coherence tomography angiography (OCT-A) showed an obstruction of the cil...
Source: Archivos de la Sociedad Espanola de Oftalmologia - Category: Opthalmology Tags: Arch Soc Esp Oftalmol Source Type: research
CONCLUSION: The prednisolone acetate was not superior to the use of sodium diclofenac or artificial tears in relieving the signs and symptoms of viral conjunctivitis. PMID: 32049186 [PubMed - in process]
Source: Acta Cirurgica Brasileira - Category: Surgery Authors: Tags: Acta Cir Bras Source Type: research
CONCLUSIONS: Evidence is lacking for major chronic palmoplantar pustulosis treatments such as superpotent corticosteroids, phototherapy, acitretin, methotrexate, and ciclosporin. Risk of bias and imprecision limit our confidence. Maxacalcitol may be more effective than placebo in achieving clearance in the short term (low-quality evidence), and the risk of adverse effects is probably similar (moderate-quality evidence). Oral alitretinoin is probably no more effective than placebo in reducing severity, with a similar risk of adverse effects (moderate-quality evidence). Regarding biological treatments, we are uncertain of th...
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research
AbstractAtopic keratoconjunctivitis (AKC) is the most severe form of allergic conjunctivitis and, if inadequately treated, can cause vision loss. Treatment aims to minimize symptoms, recurrence and consequent eye rubbing, which cause long-term eye damage. First-line treatment generally involves the use of topical ophthalmic formulations of mast-cell stabilizers and/or antihistamines, corticosteroids, calcineurin inhibitors and immunomodulators (used in that order). Systemic formulations of these drugs can be used to treat refractory cases of AKC or when deemed appropriate for the individual.
Source: Drugs and Therapy Perspectives - Category: Drugs & Pharmacology Source Type: research
CONCLUSIONS: Dupilumab alone or with TCS improved signs and symptoms of AD, had an acceptable safety profile, and suppressed biomarkers of type 2 inflammation compared to placebo in Japanese adult patients with moderate-to-severe AD. PMID: 31564057 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - Category: Dermatology Authors: Tags: Br J Dermatol Source Type: research
ConclusionReA may be decreasing in frequency and severity in Canada. Changes could be due to less food borne illness, cleaner water, or more rapid treatment of sexually transmitted infections. The cause is often unknown in clinical practice.Key Points•Reactive arthritis (ReA) is likely decreasing in prevalence and severity.• Patients with classic trial of arthritis, urethritis, and conjunctivitis are more likely to have recurrent and/or chronic ReA.• The causal organisms are often not detected and seem to be changing over time.
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
The objective of this review is to raise awareness among dermatologists regarding the potential ocular adverse effects of various AD therapies, including corticosteroids, calcineurin inhibitors, an interleukin-4 receptor  α (IL-4Rα) antagonist, and phototherapy. Pertinent potential short- and long-term risks of these therapies include elevations in intraocular pressure from use of topical corticosteroids and conjunctivitis from use of dupilumab. Since some of these adverse effects may not exhibit symptomatology u ntil permanent vision impairment occurs, it is important for dermatologists to understand thes...
Source: American Journal of Clinical Dermatology - Category: Dermatology Source Type: research
Conclusions: Corticosteroids, in combination with anti-infectives, could be a promising treatment option for acute conjunctivitis subject to development of further evidence on their effectiveness and safety in conjunctivitis treatment.
Source: Cornea - Category: Opthalmology Tags: Review Source Type: research
More News: Allergy & Immunology | Conjunctivitis | Corticosteroid Therapy | Health | Opthalmology | Restasis