Non-invasive measurements of respiratory system mechanical properties by the forced oscillation technique in spontaneously breathing, mixed-breed, normal term lambs from birth to five months of age
Objective : To provide a non-invasive approach to monitoring lung function in spontaneously
breathing lambs, from birth to five months of life, by the forced oscillation technique (FOT). This
report describes the experimental set-up, data processing, and identification of normal predicted
values of resistance (Rrs) and reactance (Xrs) of the respiratory system, along with normal
bronchodilator response for bronchial reversibility testing. Approach : Rrs and Xrs at 5, 11, and 19
Hz were measured monthly for five months in 20 normal term lambs that breathed spontaneously. In
seven lambs, repeated measurements also were made within the first month of life (at 3, 7, 14, and
21 d of life). We determined the repeatability and reproducibility of the measurements and
characterized the relationship between lung mechanics and age, sex, and body dimensions, using
regression analysis, and measured changes in lung mechanics in response to inhaled bronchodilator.
Main results
Source: Physiological Measurement - Category: Physiology Authors: Chiara Veneroni, Mar Janna Dahl, Anna Lavizzari, Elaine Dawson, Andrew Rebentisch, Sean Studstill, Sydney Bowen, Kurt H Albertine and Raffaele L Dellaca Source Type: research
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