Age-dependent effects of caloric restriction on mTOR and ubiquitin-proteasome pathways in skeletal muscles

In conclusion, CR-induced reduction of content/ phosphorylation levels of key proteins in mTOR signaling and the UPP occurred in the middle-aged rats but not younger rats. The age-dependent effects of CR on mTOR signaling and the UPP indirectly explained the age-related effects of CR on muscle mass of animals.

Source: AGE - October 31, 2019 Category: Geriatrics Source Type: research