G-PUR ® for Symptomatic Treatment in Irritable Bowel Syndrome With Diarrhea

Condition:   Irritable Bowel Syndrome With Diarrhea (IBS-D) Interventions:   Device: 2.0g G-PUR®, oral administration;   Device: Placebo, oral administration Sponsor:   Glock Health, Science and Research GmbH Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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This study aimed to investigate the impact of the update on patients with irritable bowel syndrome (IBS) in China.Methods: A previous database including consecutive patients with FGIDs (according to Rome III criteria) from gastrointestinal department of a tertiary hospital in China was re-analyzed. Demographic information, clinical symptoms, psychological status (Zung self-rating scale), and sleep quality (Pittsburgh sleep quality index) were compared between patients with Rome III and Rome IV IBS.Results: Of the 946 patients with FGIDs, only 58 (6.1%) were diagnosed with Rome IV IBS [less than 292 (30.9%) under Rome III c...
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
(Natural News) One of the challenges of treating irritable bowel syndrome (IBS) is its unclear etiology. However, a recent study revealed that its symptoms are closely linked to both gut and brain health. The study – a collaboration among researchers from the University of Gothenburg in Sweden, Katholieke Universiteit Leuven in Belgium, and the University of North Carolina at...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
Populations of microbes and their metabolites differ between patients with irritable bowel syndrome and controls, and patients with vs without bile acid malabsorption. It is not clear whether these differences contribute to development or are a product of irritable bowel syndrome.
Source: Gastroenterology - Category: Gastroenterology Authors: Source Type: research
Abstract Chronic Pelvic Pain Syndrome (CPPS) and Irritable Bowel Syndrome in Professional Overload Abstract. Chronic pelvic floor pain syndrome (CPPS) and irritable bowel syndrome are exclusion diagnoses and are subsumed under somatoform disorders in ICD-10. The CPPS includes a variety of synonyms and is treated in an interdisciplinary manner. The causes are manifold and subject to the bio-psycho-social aspects. Often the chronic pain syndrome has its origin in a somatic cause that continues despite healing of the lesion, possibly due to mental comorbidities and social stressors. Irritable bowel syndrome has chang...
Source: Praxis - Category: General Medicine Authors: Tags: Praxis (Bern 1994) Source Type: research
AbstractThe aim of this state-of-the-art narrative review is to evaluate the current evidence about the effectiveness of yoga as therapy for IBS and explore its potential mechanisms of action. The current literature suggests yoga is effective and safe and may target multiple mechanisms involved in treatment of IBS. Evidence from randomized controlled trials identified yoga as more effective compared to pharmacological treatment and equally effective as dietary interventions or moderate-intensity walking. Improvements were seen in both physical health (IBS symptom severity, gastric motility, autonomic and somatic symptom sc...
Source: Digestive Diseases and Sciences - Category: Gastroenterology Source Type: research
Authors: Masuy I, Pannemans J, Tack J Abstract Irritable bowel syndrome (IBS) is one of the most common functional gastrointestinal disorders (FGIDs) encountered in clinical practice. In the absence of an accurate biomarker for the disorder, IBS is mainly diagnosed based symptomology using the Rome criteria. Due to the heterogeneity of the disorder, finding the correct treatment option is often challenging. In general, lifestyle and dietary changes, including the low-FODMAP of gluten-free diet, are the first-in-line treatment for all patients. Issues with dietary changes are the strict elimination of multiple food ...
Source: Minerva Gastroenterologica e Dietologica - Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research
Abstract Background: Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder with recurrent abdominal pain and altered defecation habits. We here attempted to determine the effect of acupuncture on IBS. Methods: Randomized controlled trials (RCTs) published in CNKI, VIP, Wanfang, PubMed, Cochrane Library, EMBASE, Web of science, and ClinicalTrials.gov till July 17, 2019 were searched. Outcomes were total efficacy rates, overall IBS symptom scores, or global quality of life scores. Standardized mean difference (SMD) with 95% confidence intervals (CI) and risk ratio (RR) with 95% CI were calcul...
Source: Pain Research and Management - Category: Anesthesiology Authors: Tags: Pain Res Manag Source Type: research
Condition:   Irritable Bowel Syndrome Interventions:   Drug: Melatonin and standard therapy for IBS;   Other: Standard medical therapy and placebo Sponsor:   Sanjay Gandhi Postgraduate Institute of Medical Sciences Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
In conclusion, this study demonstrates that the Clostridia-rich microbiota contributes to excessive BA excretion in IBS-D patients, which provides a mechanistic hypothesis with testable clinical implications.
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Excessive fecal bile acid (BA) loss causes symptoms in a large proportion of people diagnosed with irritable bowel syndrome with diarrhea, a common functional bowel disorder. This BA diarrhea (BAD) results from increased hepatic synthesis of BAs, with impaired negative feedback regulation by the ileal hormone fibroblast growth factor 19 (FGF19). In this issue of the JCI, Zhao et al. investigated BA metabolism, including fecal BAs, serum BAs, and FGF19, in patients and controls. They identified associations between fecal bacterial BA metabolism and specific microbiota, especially Clostridium scindens. These findings have be...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
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