Safety and Efficacy Assessment of HAV (Manufactured Using Large-scale System) in Patients Needing Vascular Access for Dialysis

Conditions:   Renal Failure;   End Stage Renal Disease;   Vascular Access;   Hemodialysis Intervention:   Biological: HAV Sponsor:   Humacyte, Inc. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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ConclusionMuscle functionality and quality can predict hospitalization and overall survival in chronic hemodialysis patients, better than muscle mass.
Source: Journal of the Formosan Medical Association - Category: General Medicine Source Type: research
Publication date: Available online 17 November 2019Source: Pharmacological ResearchAuthor(s): Moein Askarpour, Amir Hadi, Maryam Miraghajani, Michael Symonds, Ali Sheikhi, Ehsan GhaediAbstractDespite preclinical studies demonstrating the efficacy of L-carnitine supplementation for weight management, findings in clinical setting are contradictory. Electronic bibliographical databases were systematically searched up to February 2019 with no limitation in language, including Scopus, PubMed, ISI Web of Science and Cochrane Library. Clinical trials registry platform were also searched. All randomized controlled trials (RCTs) wh...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
ConclusionsHemodialysis patients with central obesity, as measured by the A/G ratio, had less favorable plasma lipid profiles and higher levels of inflammation but not an increased risk of ASCVD.
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
This study aims to analyze the prevalence and to concentrate on the key risk factors that are responsible for hepatitis B virus (HBV), hepatitis C virus (HCV), and human immunodeficiency virus (HIV) infection in patients on HD visiting two dialysis centers in the city of Quetta in southwestern Pakistan. The overall incidence of HBV was found to be 16.1%, the overall incidence of HCV was found to be 43.2%, and two patients (1.6%) were found to be positive for both HBV and HCV. HIV was not found among patients seen at both hospitals during the study period. The main risk factors for development of a viral infection were the ...
Source: Drug Discoveries and Therapeutics - Category: Drugs & Pharmacology Tags: Drug Discov Ther Source Type: research
Women with ESRD on hemodialysis are rarely screened for osteoporosis despite the fact they are at high risk for bone diseases compared with the general population.Medscape Medical News
Source: Medscape Diabetes Headlines - Category: Endocrinology Tags: Nephrology News Source Type: news
Conditions:   End Stage Renal Disease;   Hypertension;   Extracellular Volume Overload;   Intradialytic Hypotension Intervention:   Other: IBPS-Guided Ultrafiltration Sponsor:   VA Office of Research and Development Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
ConclusionConventional HD resulting in substantial plasma volume removal do not alter large artery elastic properties, whereas intrinsic microvascular venular dilator function is markedly impaired, an effect directly associated with the increase in hemoconcentration.
Source: Microvascular Research - Category: Biochemistry Source Type: research
Inflammaging is a persistent, low −grade, sterile, nonresolving inflammatory state, associated with the senescence of the immune system. Such condition downregulates both innate and adaptive immune responses du...
Source: BMC Nephrology - Category: Urology & Nephrology Authors: Tags: Research article Source Type: research
ABSTRACTBackgroundTrends and clinical factors associated with prescribing choices for oral P2Y12 inhibitors (P2Y12-I) remain unknown for patients on chronic dialysis, i.e., with end-stage renal disease (ESRD).MethodsFrom 2011 –2014 U.S. Renal Data System registry, we identified 36,542 ESRD patients who received new prescriptions for P2Y12-I (median age 64.0 years and 54% males). Of the cohort, 93% were receiving hemodialysis and 7% on peritoneal dialysis. We analyzed trends and investigated clinical factors associated with specific P2Y12-I prescribed.ResultsClopidogrel was prescribed for 95%, prasugrel for 3%, and ti...
Source: Cardiovascular Drugs and Therapy - Category: Cardiology Source Type: research
ConclusionAlthough the rates of LAM related complications were unexpectedly high in the long term, LT is a feasible therapeutic option for patients with advanced pulmonary LAM.
Source: The Clinical Respiratory Journal - Category: Respiratory Medicine Authors: Tags: ORIGINAL ARTICLE Source Type: research
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