Interleukin17 –CXCR2 axis facilitates breast cancer progression by up-regulating neutrophil recruitment

Recent evidence suggests that interactions among pro-inflammatory cytokines, chemokines, and cancer cell –recruited neutrophils result in enhanced metastasis and chemotherapy resistance. Nonetheless, the detailed mechanism remains unclear. Our aim was to discover the role of interleukin 17 (IL-17), CXCR2 ligands, and cancer-associated neutrophils in chemotherapy resistance and metastasis in breast ca ncer. Mice were injected with Cl66 murine mammary tumor cells, Cl66 cells resistant to doxorubicin (Cl66-Dox), or paclitaxel (Cl66-Pac).
Source: American Journal of Pathology - Category: Pathology Authors: Tags: Regular Article Source Type: research