Girl awakes after lung transplant

Sarah Murnaghan, the Philadelphia girl who underwent a lung transplant last week following a court battle, is out of a coma and responsive.
Source: CNN.com - Health - Category: Consumer Health News Source Type: news

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This study provides a possible reason why genes carrying health risks have persisted in human populations. The second found evidence for multiple variants in genes related to ageing that exhibited antagonistic pleiotropic effects. They found higher risk allele frequencies with large effect sizes for late-onset diseases (relative to early-onset diseases) and an excess of variants with antagonistic effects expressed through early and late life diseases. There also exists other recent tangible evidence of antagonistic pleiotropy in specific human genes. The SPATA31 gene has been found under strong positive genomic sele...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
We present a CF-patient with disseminated Scedosporium apiospermum infection after lung transplantation. The patient had skin, surgical wound, spinal cord, and brain involvements. She recovered fully after prolonged course of voriconazole treatment.
Source: Medical Mycology Case Reports - Category: Biology Source Type: research
We have applied cutting-edge mass cytometry (MC) technology to serial bronchoalveolar lavage (BAL) cells obtained from lung transplant recipients (LTRs) and have used it to compare the cellular composition of the BAL compartment in patients who remain stable or go on to develop lung allograft dysfunction (LAD), defined here as a drop, from any cause, in the forced expiratory volume in 1 second of 20% from the best post-transplant baseline value.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 17 Source Type: research
We examined the ratio of regulatory T cells (Tregs, which express Foxp3) to T effector cells (Teff) in TBBx as a predictor of outcome.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 16 Source Type: research
Long-term survival after lung transplantation (LTx) is hampered by chronic lung allograft dysfunction, with bronchiolitis obliterans syndrome (BOS) as its most common phenotype. Bronchiectasis (BRECT), hyperinflation and airtrapping are considered the key features of BOS on chest CT. We investigated whether chest CT and key features have prognostic value at BOS diagnosis in patients with established BOS after LTx.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 15 Source Type: research
Chronic Allograft Dysfunction (CLAD) with Bronchiolitis obliterans (BOS) phenotype is a major limitation for long term survival after lung transplantation (LT). Predictive biomarkers for BOS are unavailable. Purpose of our study was to establish a tractable system to evaluate the effects of pre-transplant antibodies to self-antigens (AutoAbs) and to examine specific patterns that correlate with BOS.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 14 Source Type: research
Chronic lung allograft dysfunction (CLAD) is a clinical/functional diagnosis that cannot be defined by histology in transbronchial biopsies (TBBs). Moreover, understanding the biology of CLAD is crucial for prevention and potential treatment. We studied gene expression associated with CLAD in TBBs, but also studied mucosal biopsies from the third bronchial bifurcation (3BMBs).
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 13 Source Type: research
The DLCO measures the capacity of the lungs to exchange gas across the alveolar-capillary interface. We hypothesized that DLCO is a sensitive measure of injurious allograft processes that can disrupt this interface. Our goals were to describe the trajectory of DLCO measurements after lung transplantation, and to determine the prognostic significance of DLCO on chronic lung allograft dysfunction (CLAD) and survival.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 12 Source Type: research
Ex vivo lung perfusion (EVLP) has been proposed as a platform for lung graft assessment and preservation. However, its proinflammatory milieu may be associated with deterioration in graft quality which may contribute to posttransplant graft dysfunction. Triptolide (TL), a diterpenoid triepoxide, has recently been shown to have a therapeutic potential in various disease states due to its anti-inflammatory properties. Based on this, we sought to assess the impact of TL on graft preservation during EVLP as well as associated posttransplant outcomes.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 11 Source Type: research
We investigated whether atorvastatin can alleviate diabetic cardiomyopathy (DM CMP) by reducing intracellular matrix metalloproteinase-2 (MMP-2) isoform expression.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 10 Source Type: research
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