taVNS for Upper Limb Rehabilitation

Condition:   Stroke Intervention:   Device: Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) + Task Specifc Training Sponsors:   Medical University of South Carolina;   National Institutes of Health (NIH);   National Institute of General Medical Sciences (NIGMS) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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Abstract Numerous preclinical studies demonstrate that vagus nerve stimulation (VNS) paired with motor rehabilitation improves functional recovery after neural injuries such as stroke, traumatic brain injury, and spinal cord injury, in part by driving neural plasticity within the motor cortex. To date, these studies have been performed almost exclusively in female rats, however, the risk for neural injuries of all types is significantly higher among males than females. We therefore sought to determine whether VNS was equally effective at driving motor cortical plasticity in both sexes. Male and female rats were tr...
Source: Brain Research - Category: Neurology Authors: Tags: Brain Res Source Type: research
The objective of this study is to investigate the effect and safety of taVNS on upper limb motor function in subacute ischemic stroke patients. Methods: Twenty-one subacute ischemia stroke patients with single upper limb motor function impairment were enrolled and randomly assigned to conventional rehabilitation training with real or sham taVNS, delivered for 15 consecutive days. Electrodes were fixed to the cymba conchae of the left ear with or without electrical stimulation. Conventional rehabilitation training was performed immediately after the end of real or sham taVNS by the same therapists. Baseline assessments...
Source: Neural Plasticity - Category: Neurology Authors: Tags: Neural Plast Source Type: research
AbstractVagus nerve stimulation (VNS) paired with rehabilitative training enhances recovery of function in models of stroke and is currently under investigation for use in chronic stroke patients. Dosing is critical in translation of pharmacological therapies, but electrical stimulation therapies often fail to comprehensively explore dosing parameters in preclinical studies. Varying VNS parameters has non-monotonic effects on plasticity in the central nervous system, which may directly impact efficacy for stroke. We sought to optimize stimulation intensity to maximize recovery of motor function in a model of ischemic strok...
Source: Translational Stroke Research - Category: Neurology Source Type: research
Publication date: Available online 19 May 2020Source: Neuroscience LettersAuthor(s): Jiani Li, Qinbin Zhang, Sheng Li, Lingchuan Niu, Jingxi Ma, Lan Wen, Lina Zhang, Changqing Li
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
Neonates born premature or who suffer brain injury at birth often have oral feeding dysfunction and do not meet oral intake requirements needed for discharge. Low oral intake volumes result in extended stays in the hospital (>2 months) and can lead to surgical implant and explant of a gastrostomy tube (G-tube). Prior work suggests pairing vagus nerve stimulation (VNS) with motor activity accelerates functional improvements after stroke, and transcutaneous auricular VNS (taVNS) has emerged as promising noninvasive form of VNS. Pairing taVNS with bottle-feeding rehabilitation may improve oromotor coordination and lead to ...
Source: Frontiers in Human Neuroscience - Category: Neuroscience Source Type: research
The vagus nerve plays an important role in maintaining physiological homeostasis, which includes reflex pathways that regulate cardiac function. The link between vagus nerve activity and the high-frequency component of heart rate variability (HRV) has been well established, correlating with vagal tone. Recently, vagus nerve stimulation (VNS) has been investigated as a therapeutic for a multitude of diseases, such as treatment-resistant epilepsy, rheumatoid arthritis, Crohn's disease, and asthma. Because of the vagus nerve's innervation of the heart, VNS has been identified as a potential therapy for cardiovascular disorder...
Source: Cold Spring Harbor perspectives in medicine - Category: Research Authors: Tags: Bioelectronic Medicine TECHNIQUES Source Type: research
Conditions:   Stroke;   Stroke Sequelae;   Motor Activity Interventions:   Device: Transcranial Magnetic Stimulation;   Device: transcutaneous auricular vagus nerve stimulation (taVNS) Sponsors:   Medical University of South Carolina;   National Institutes of Health (NIH) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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