Magnitude of Therapeutic STING Activation Determines CD8+ T Cell-Mediated Anti-tumor Immunity

Publication date: 15 October 2019Source: Cell Reports, Volume 29, Issue 3Author(s): Kelsey E. Sivick, Anthony L. Desbien, Laura Hix Glickman, Gabrielle L. Reiner, Leticia Corrales, Natalie H. Surh, Thomas E. Hudson, Uyen T. Vu, Brian J. Francica, Tamara Banda, George E. Katibah, David B. Kanne, Justin J. Leong, Ken Metchette, Jacob R. Bruml, Chudi O. Ndubaku, Jeffrey M. McKenna, Yan Feng, Lianxing Zheng, Steven L. Bender
Source: Cell Reports - Category: Cytology Source Type: research

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Publication date: 16 November 2019Source: New Scientist, Volume 244, Issue 3256Author(s): Erin Murphy
Source: New Scientist - Category: Science Source Type: research
George SelginYou ’ve always had the power to go back to Kansas.–the Good Witch of the East, to Dorothy, inThe Wizard of Oz(This is the conclusion of a two-part essay. For Part 1 clickhere.)Equipped with some historical background, we can now consider ways in which the Fed might get the Treasury and Foreign Official Institutions (FOIs) to revive their pre-crisis practice of parking surplus dollars somewhere other than at the Fed. In fact, most of the necessary means are already at hand. Fed officials only need to recognize and take advantage of them. They need, as it were, to click the heels of their ruby slippe...
Source: Cato-at-liberty - Category: American Health Authors: Source Type: blogs
io FZ, Gurrola GB, Possani LD Abstract Every year in Mexico, around 300,000 people suffer from accidents related to scorpion stings. Among the scorpion species dangerous to human is Centruroides ornatus, whose venom characterization is described here. From this venom, a total of 114 components were found using chromatographic separation and mass spectrometry analysis. The most abundant ones have molecular masses between 3000-4000 Da and 6000-8000 Da respectively, similar to other known K+ and Na+-channel specific scorpion peptides. Using intraperitoneal injections into CD1 mice, we were able to identify and fu...
Source: Toxicon - Category: Toxicology Authors: Tags: Toxicon Source Type: research
This study underscores the capacity of human DC to discriminate between live and inactivated S. aureus and, further, indicates that DC may represent a valuable experimental setting to test different inactivation methods with regard to the retention of S. aureus immunoregulatory properties. These and further insights may be useful for the development of novel therapeutic and prophylactic anti-S. aureus vaccine strategies.
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
In recent years, I’ve encountered a growing number of parents in my therapy practice who come to me fearing that their child has oppositional defiant disorder (ODD). According to the American Psychiatric Association, the primary signs of ODD are angry and irritable mood, argumentative and defiant behavior, and vindictiveness. Often these parents will share that a teacher or doctor told them their child may have ODD, and that when they looked up the condition online, they recognized some of the symptoms in their child’s behavior. As a parent myself, the worry and confusion on my clients’ faces and, in the...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Agitation Children and Teens Parenting Stigma Students Child Development difficult child Oppositional Defiant Disorder Source Type: blogs
The feeling of abandonment can span through all types of relationships and in this episode, we focus on friendships. Have you ever had a close friend abandon you or have you ever exited a friendship without notice? The emotions and actions surrounding the abandonment of friends can be complex and hurtful, but they are very real and can hurt deeply.  In this episode, Jackie recounts friendships that were very important to her and how she’s handling the loss of them. (Transcript Available Below) SUBSCRIBE &REVIEW About The Not Crazy Podcast Hosts Gabe Howard is an award-winning writer and speaker who live...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Communication Family Friends General Grief and Loss Not Crazy Podcast Relationships Source Type: blogs
Answer toParasite Case of the Week 568: Pseudoscorpion or false scorporion, not a human parasite.This fun little arthropod is occasionally submitted to the clinical laboratory for identification, and may be mistaken as a true scorpion. While both scorpions and pseudoscorpions are arachnids, pseudoscorpions are very small (1 cm or less in length) andlack a tail with a stinger. As sylvie g and Santiago note, pseudoscorpions can occasionally be found in the house, but they don't bite or sting humans, and instead feed on other small arthropods such as booklice.Thanks again to Old One and his son for the donation of the cool animated illustration.
Source: Creepy Dreadful Wonderful Parasites - Category: Parasitology Source Type: blogs
Twenty-six years after the arrival of “killer bees” in Arizona, the entire state with the exception of high elevations in the north is populated with this bee variety and 11 people have died at the scene of massive bee attacks.
Source: The American Journal of Medicine - Category: General Medicine Authors: Source Type: research
ConclusionsNew clinical aspect of diffuse alveolar hemorrhage is first reported to be associated with SAVI. Unsatisfactory therapeutic effects of tofacitinib are observed in this study and further evaluations are needed.
Source: Journal of Clinical Immunology - Category: Allergy & Immunology Source Type: research
Toxoplasma gondii is an important neurotropic pathogen that establishes latent infections in humans that can cause toxoplasmosis in immunocompromised individuals. It replicates inside host cells and has developed several strategies to manipulate host immune responses. However, the cytoplasmic pathogen-sensing pathway that detects T. gondii is not well-characterized. Here, we found that cyclic GMP-AMP synthase (cGAS), a sensor of foreign dsDNA, is required for activation of anti-T. gondii immune signaling in a mouse model. We also found that mice deficient in STING (Stinggt/gt mice) are much more susceptible to T. gondii in...
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: Editors ' Picks Source Type: research
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