The role of animal models in elucidating the etiology and pathology of abdominal aortic aneurysms: Development of a novel rupture mechanism model

Existing animal models do not replicate all aspects of abdominal aortic aneurysms (AAAs), including the rupture mechanisms. From histopathological analyses conducted in humans, it has been found that the vasa vasorum (VV) of the AAA wall is the starting point of circulatory failure and that bulging and dilatation of the abdominal aorta occurs through inflammation and tissue degeneration. We created a new animal model (the hypoperfusion-induced model) of AAAs. In this paper, we describe the current animal models of AAAs and present the utility of our new model of AAAs.

Source: Annals of Vascular Surgery - October 14, 2019 Category: Surgery Authors: Hiroki Tanaka, Nobuhiro Zaima, Hirona Kugo, Tatsuro Yata, Yasunori Iida, Keisuke Hashimoto, Chie Miyamoto, Takeshi Sasaki, Hideto Sano, Yuko Suzuki, Tatsuya Moriyama, Hideyuki Shimizu, Kazunori Inuzuka, Tetsumei Urano, Naoki Unno Tags: General Review Source Type: research