Injectable Self-Healing Hydrogels Based on Boronate Ester Formation between Hyaluronic Acid Partners Modified with Benzoxaborin Derivatives and Saccharides.

Injectable Self-Healing Hydrogels Based on Boronate Ester Formation between Hyaluronic Acid Partners Modified with Benzoxaborin Derivatives and Saccharides.
Biomacromolecules. 2019 Oct 14;:
Authors: Figueiredo T, Jing J, Jeacomine I, Olsson J, Gerfaud T, Boiteau JG, Rome C, Harris C, Auzély-Velty R
Abstract
We demonstrate here, for the first time, formation of injectable dynamic covalent hydrogels at physiological pH using benzoxaborin-saccharide complexation as a reversible cross-linking method. The gels were prepared by simply mixing hyaluronic acid modified with an original boronic acid derivative, 3,4-dihydro-2H-benzo[e][1,2]oxaborinin-2-ol (1,2-ABORIN), and HA functionalized with 1-amino-1-deoxy-d-fructose. Dynamic rheological experiments confirmed the gel-like behavior (storage modulus (G') > loss modulus (G″) in the frequency window explored) for the designed HA-1,2-ABORIN/HA-fructose network. Furthermore, this hydrogel exhibited excellent self-healing and injectability behaviors in aqueous conditions and was found to be responsive to pH. Additionally, fibroblast cells encapsulated in the HA network showed high viability (>80% after 7 days of cell culture), as monitored by Live/Dead staining. Taken together, this new class of boronate ester cross-linked hydrogel provides promising future for diverse biomedical applications.
PMID: 31609592 [PubMed - as supplied by publisher]

Source: Biomacromolecules - October 13, 2019 Category: Biochemistry Authors: Figueiredo T, Jing J, Jeacomine I, Olsson J, Gerfaud T, Boiteau JG, Rome C, Harris C, Auzély-Velty R Tags: Biomacromolecules Source Type: research