In A Mouse Model Of Polycystic Kidney Disease, Vitamin B3 Blocks Cyst Formation

Autosomal dominant polycystic kidney disease (ADPKD) is an inherited systemic disorder caused by mutations in PKD1 or PKD2 that predominately affects the kidneys and is characterized by the formation of cysts in the kidneys and other organs. Xiaogang Li and colleagues at the University of Kansas Medical Centr used a mouse model of ADPKD to explore the role of the protein sirtuin 1 in cyst formation. They found that inhibition of sirtuin 1 activity using vitamin B3 can reduced cyst formation in the kidneys of ADPKD mice...
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Urology / Nephrology Source Type: news