Cys-LTs ’ Pro-phlogistic Lung Actions Are Regulated by Cys-Maresins

Cysteinyl-leukotrienes are potent pro-phlogistic mediators in asthma. Here, metabololipidomic profiling showed that maresin conjugates in tissue regeneration (MCTRs) were abundant in lung, blocked LTD4-initiated human airway contraction, and accelerated murine allergic lung resolution of inflammation.

Source: Journal of Allergy and Clinical Immunology - October 13, 2019 Category: Allergy & Immunology Authors: Bruce D. Levy, Raja-Elie E. Abdulnour, Alexander Tavares, Thayse R. Br üggemann, Paul C. Norris, Yan Bai, Xingbin Ai, Charles N. Serhan Source Type: research