Development of 4-oxime-1,8-naphthalimide as a bioorthogonal turn-on probe for fluorogenic protein labeling.

Development of 4-oxime-1,8-naphthalimide as a bioorthogonal turn-on probe for fluorogenic protein labeling.
Chem Commun (Camb). 2019 Oct 10;:
Authors: Tian Y, Li X, Yin D
Abstract
4-Oxime-1,8-naphthalimide was reported as a novel bioorthogonal turn-on probe based on 1,3-dipolar cycloaddition reactions between in situ generated nitrile oxide and alkenes/alkynes. The resulting isoxazole products displayed dramatically strong fluorescence enhancement upon photoirradiation through isoxazole-oxazole photoisomerization. This new methodology was successfully applied for in situ fluorogenic protein labeling.
PMID: 31599283 [PubMed - as supplied by publisher]

Source: Chemical Communications - October 9, 2019 Category: Chemistry Authors: Tian Y, Li X, Yin D Tags: Chem Commun (Camb) Source Type: research