E-cigarette 'smoke' gave nearly one in four mice lung cancer
For a year, researchers at New York University exposed 40 mice to e-cigarette vapor. Nine of them developed lung cancer - but the animals exposed to nicotine-free 'smoke' did not.
Publication date: Available online 21 October 2019Source: Life SciencesAuthor(s): Yu Dong, Tao Xu, Shouping Zhong, Bo Wang, Huimin Zhang, Xin Wang, Peng Wang, Guangshun Li, Shuanying YangAbstractAimsCircular RNAs (circRNAs) acted as key regulators in the development of various human tumors. Our present study aimed to investigate the role and molecular mechanism of circ_0076305 in regulating cisplatin (DDP) resistance of non-small cell lung cancer (NSCLC).Main methodsUsing RT-qPCR, the expressions of circ_0076305 in NSCLC tissues and cells (A549, H1650, A549/DDP, H1650/DDP) were measured. Through loss-of-function and overex...
CONCLUSIONWe report a case of laparoscopic hepatectomy for liver metastasis of lung LCNEC. It is suggested that surgical resection for solitary distant metastasis of LCNEC may improve prognosis.
Publication date: Available online 21 October 2019Source: European Journal of RadiologyAuthor(s): Xueru Zhu, Xiaoyang Li, Hengle Gu, Wen Yu, Xiaolong FuAbstractPurposeTo analyze radiation-induced lung injury (RIL) after stereotactic body radiotherapy (SBRT) of lung cancer and the subsequent clinical problems.Methods106 lung cancer patients treated with SBRT were included, their computed tomography (CT) scans were reviewed. Late injury pattern was classified by Koening’s, radiologist’ diagnosis reports for RIL was reviewed. Logistic regression was used to analyze the predictive model of injury pattern, which was...
Researchers from the University of Leeds and University of Exeter have called for X-rays, which cost £25 a pop, to be scrapped as the first-line test for lung cancer (file)
Men who are current or former smokers may be less likely to develop or die from lung cancer when they're more physically fit, a recent study suggests.Reuters Health Information
Eupafolin is the main bioactive component extracted from the traditional Chinese medicine Ay Tsao (Artemisia vulgaris L.), and its anti-tumor activity has had been studied in previous researches. T-LAK cell-originated protein kinase (TOPK) belongs to serine/threonine protein kinase and is highly expressed in several cancer cells and tissues, such as colon cancer, lung cancer, esophagus cancer, and so on. Therefore, it was recognized as an important target for treating tumors. Nowadays, we found that eupafolin suppressed TOPK activities at the first time in vitro and in vivo. The cells study indicated that eupafolin suppres...
GPs could consider additional imaging Related items fromOnMedica Metastatic breast cancer goes undiagnosed for too long NICE updates lung cancer guidance NHS must improve access to screening to save lives GP gatekeepers linked to reduced patient satisfaction Black and young women have double risk of triple-negative breast cancer
In conclusion, AFAP1-AS1 promoted chemotherapy resistance by supressing miR-139-5p expression and promoting RRM2/EGFR/AKT signaling pathway in NSCLC cells.
Conclusions: Crizotinib was effective and well tolerated in Chinese patients with ALK-positive, advanced NSCLC in real-world clinical practice. For patients without BBM, crizotinib as first-line therapy can lead to a longer PFS than second-or later line therapy. CBPD plus local therapy after 1st PD beyond crizotinib is feasible and effective in clinical routine practice.
Conclusion: Life-gained-based selection could maximize the benefits of lung cancer screening in the U.S. population by including ever-smokers who have both high lung cancer risk and long life expectancy. Primary Funding Source: Intramural Research Program of the National Cancer Institute, National Institutes of Health. PMID: 31634914 [PubMed - as supplied by publisher]