Human STAT5b mutation causes dysregulated human natural killer cell maturation and impaired lytic function

Capsule summary: In humans, the absence of STAT5b mimics the abrogated NK cell terminal maturation observed in Stat5b-/- mice. NK cells from STAT5b patients had a decreased cytolytic function and impaired convergence of lytic granules to the microtubule-organizing center.

Source: Journal of Allergy and Clinical Immunology - October 6, 2019 Category: Allergy & Immunology Authors: Alexander Vargas-Hern ández, Agnieszka Witalisz-Siepracka, Michaela Prchal-Murphy, Klara Klein, Sanjana Mahapatra, Waleed Al-Herz, Emily M. Mace, Alexandre F. Carisey, Jordan S. Orange, Veronika Sexl, Lisa R. Forbes Source Type: research