Kindlin-3 stokes the life span of podosomes

Macrophages and other cell types can form podosomes, highly dynamic adhesive structures that mediate the interaction of these cells with the surrounding matrix. In this issue, Klapproth et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201903109) find that kindlin-3 regulates podosome stability by recruiting leupaxin, with concomitant effects on PTP-PEST phosphatase activity and paxillin phosphorylation.

Source: Journal of Cell Biology - October 6, 2019 Category: Cytology Authors: Zhang, H. Tags: Spotlight Source Type: research