3.2 do baseline neural connectivity and individual variability during executive function task performance predict treatment response to repetitive transcranial magnetic stimulation (rtms) for executive function deficits in youth and young adults with asd?

Executive function (EF) deficits in individuals with ASD are ubiquitous and understudied. The dorsolateral prefrontal cortex (DLPFC), the central hub of the fronto-parietal network supporting EF, is a promising treatment target for repetitive transcranial magnetic stimulation (rTMS) to improve EF. Here, we examine individual variability in functional connectivity (FC) in ASD at baseline, in the context of an RCT examining the effect of rTMS on EF deficits in ASD. Given the clinical and neural heterogeneity of ASD, our aim was to identify neural markers predictive of treatment response to personalize treatment approaches for this target.
Source: Journal of the American Academy of Child and Adolescent Psychiatry - Category: Psychiatry Authors: Source Type: research