Collisions on the Busy DNA Highway Set Up Barriers for Reprogramming.

Collisions on the Busy DNA Highway Set Up Barriers for Reprogramming.
Cell Stem Cell. 2019 Oct 03;25(4):451-453
Authors: Hu X, Guo S
Abstract
Why most cells remain refractory to transcription factor (TF)-induced fate conversion remains largely mysterious, with the answers holding important instructions on how to effectively direct cell identities. In this issue of Cell Stem Cell, Babos et al. (2019) show that conflicts caused by simultaneous high transcription and high replication rates are to blame.
PMID: 31585090 [PubMed - in process]

Source: Cell Stem Cell - October 2, 2019 Category: Stem Cells Authors: Hu X, Guo S Tags: Cell Stem Cell Source Type: research