Aspidsaponins E-H, Four new steroidal saponins from the rhizomes of Aspidistra elatior Blume and their anti-inflammatory activity

Publication date: December 2019Source: Phytochemistry Letters, Volume 34Author(s): Zhi-Ying Sun, Sheng-Qi Zuo, Xia Yang, Jia-Hui Lan, Cheng-Xiong Liu, Zhi-Yong Guo, Fan Cheng, Kun ZouAbstractFour new furostanol saponins, named aspidsaponins E-H (1–4) were isolated from the rhizomes of Aspidistra elatior Blume. Their structures were determined based on chemical methods and spectral data. Compounds 1 and 2 were a pair of diastereoisomeric furostanol saponins and possessed the highly oxidized structural feature of 1β, 2β, 3β, 4β, 5β, 26-hexanol-steroids, and compounds 3-4 were steroidal glycosides with a tetra-saccharide chain at C3. The isolated compounds (1–4) were tested in vitro for inhibitory activities against LPS-induced nitric oxide production in RAW264.7 macrophages. Among them, compounds 3 and 4 showed excellent anti-inflammatory activities with IC50 values 82.1 and 65.9 μM, respectively.Graphical abstract

Source: Phytochemistry Letters - October 5, 2019 Category: Chemistry Source Type: research