Objective burn depth assessment of hand burns.
[Objective burn depth assessment of hand burns]. Handchir Mikrochir Plast Chir. 2019 Sep;51(5):362-366 Authors: Promny D, Billner M, Reichert B Abstract The depth assessment of thermal wounds is subject to many variables. Therefore, technical systems are increasingly being used to determine severity. Particularly hand burns can have clinically relevant consequences in terms of function and aesthetic appearance. Hence, a secure assessment for an adequate treatment is necessary.Technical analyzes such as Hyperspectral Imaging, Laser-Doppler-Imaging or Laser-Speckle-Imaging are intended to simplify and objectify the examination by helping to determine the necessary depth of necrectomy and thus to define the skin transplantation area. Furthermore, the diverse technical devices are to improve the functional result, reduce the severity of scarring and cosmetic complaints, and facilitate the evaluation of inexperienced personnel in the field of burn medicine.Therefore, various technical approaches have been pursued, which are largely based on optical principles. The respective devices are not yet used in the standard diagnosis of burn wounds.In future studies it will be necessary to determine an algorithm for the measurement intervals based on the wound dynamics and to evaluate which methodology is superior to the specificity and sensitivity. PMID: 31574550 [PubMed - in process]
Allogeneic hematopoietic cell transplantation (alloHCT) is potentially curative for hematologic malignancies and non-malignant disorders including inherited metabolic disorders, hemoglobinopathies and bone marrow failure syndromes. The optimal donor for alloHCT is an HLA identical sibling. Unfortunately, approximately 70% of patients in need of alloHCT will not have a fully matched donor in their family and must pursue an unrelated adult donor (URD), umbilical cord blood (UCB) or a mismatched related donor as a graft source.
The field of hematopoietic cell transplantation (HCT) is characterized by substantial practice variations in therapeutic approaches including preferred donor, graft source, conditioning regimens and graft-versus-host disease (GVHD) prophylaxis. Many factors influence practice but a major one is the lack of definitive data about best practices. The Blood and Marrow Transplant Clinical Trials Network (BMT CTN) conducts clinical trials that aim to define best practices and improve the outcomes of patients undergoing HCT.
Circumferential wound is most-common seen in high-energy trauma, especially in degloving injury and blunt injury. Circumferential soft-tissue defect could also be encountered in infection, burns, electrocution and congenital nevi after the involved lesion being resected . The characteristic feature is the defect involves four sides on extremities (anterior, posterior, medial and lateral), each of which could be wider or narrower. If the wound is located around the joint, the defect would have more dimensions and more irregular shape.
Conclusion: Therefore, our results indicate that iPSCs-MVs-derived miR-16-5p may be a novel therapeutic approach for deep second-degree burn wound healing.
Abstract Corneal opacities affect vision for millions of individuals worldwide. Fibrotic scar tissues accumulate in reaction to inflammatory responses and remain permanently in corneal stroma, and conventionally correctable only by donor corneal transplantation. Numerous studies have explored innovative approaches to reverse corneal scarring through non-surgical means; however, existing mouse models limit these studies, due to the lack of visibility of scar tissue in mouse corneas with steep curvature. Here, we reported that corneal scarring was modelled using a transgenic mouse line, Tg(Col3a1-EGFP)DJ124Gsat, in ...
Purpose of review To summarize the evolution of skin xenotransplantation and contextualize technological advances and the status of clinically applicable large animal research as well as prospects for translation of this work as a viable future treatment option. Recent findings Porcine xenografts at the start of the millennium were merely biologic dressings subject to rapid rejection. Since then, numerous important advances in swine to nonhuman primate models have yielded xenotransplant products at the point of clinical translation. Critical genetic modifications in swine from a designated pathogen-free donor herd hav...
The field of hematopoietic cell transplantation (HCT) has benefited from well-conducted, rigorous, multicenter randomized controlled trials; however, the implementation of study results into practice can be unpredictable [1,2]. In 2019, the Executive Committee of the Blood and Marrow Transplant Clinical Trials Network (BMT CTN) established the Task Force on Evidence into Practice and charged the it developing a framework to promote the translation of results from BMT CTN clinical trials into clinical practice.
The field of hematopoietic cell transplantation (HCT) has benefited from well-conducted, rigorous, multi-center randomized controlled trials. However, the implementation of study results into practice can be unpredictable.1, 2 In 2019, the Executive Committee of the Blood and Marrow Transplant Clinical Trials Network (BMT CTN) established the Task Force on Evidence into Practice and charged the Task Force with developing a framework to promote translation of results from BMT CTN clinical trials into clinical practice.
Conclusions: In this case, this new modified procedure was a promising, easy-to-perform, apparently safe, and effective treatment option to enhanced epithelial wound healing in ocular surface diseases. To our knowledge, this is the first report describing the incorporation of solid PRP in limbal transplantation procedures.
In this study, we measured pGSN in patients with chronic granulomatous disease (CGD), a primary immunodeficiency characterized by recurrent infections and dysregulated inflammation. pGSN was quantified using a sandwich ELISA in plasma from healthy volunteers, clinically stable CGD patients, and X-linked CGD carriers and in sera from 12 CGD patients undergoing bone marrow transplantation. pGSN was also quantified in healthy volunteers challenged with intravenous endotoxin. pGSN concentrations were lower in CGD patients without active infection or systemic inflammation compared with healthy control subjects. In CGD patients ...