Solvent-Free Synthesis of Functionalized Thiazoles Using Multicomponent Reaction of Isothiocyanates.

Solvent-Free Synthesis of Functionalized Thiazoles Using Multicomponent Reaction of Isothiocyanates.
Comb Chem High Throughput Screen. 2013 May 29;
Authors: Sayyed-Alangi SZ, Hossaini Z, Rostami-Charati F, Sajjadi-Ghotabadi H
Abstract
An efficient synthesis of thiazoles is described via an one-pot reaction between acid chlorides, ammonium thiocyanate tetramethylguanidine and α-bromocarbonyl compounds under solvent-free conditions without using any catalyst. The method offers several advantages including high yields of products and an easy work-up procedure at room temperature in excellent yield.
PMID: 23721069 [PubMed - as supplied by publisher]

Source: Combinatorial Chemistry and High Throughput Screening - May 29, 2013 Category: Chemistry Authors: Sayyed-Alangi SZ, Hossaini Z, Rostami-Charati F, Sajjadi-Ghotabadi H Tags: Comb Chem High Throughput Screen Source Type: research