Cobalt doped magnetite nanoparticles: Synthesis, characterization, optimization and suitability evaluations for magnetic hyperthermia applications

Publication date: Available online 1 October 2019Source: Physica E: Low-dimensional Systems and NanostructuresAuthor(s): Zeinab Erfani Gahrouei, Sheyda Labbaf, Ahmad KermanpurAbstractCobalt doped magnetite nanoparticle (CoxFe3-xO4 NPs) is synthesized using different amount of cobalt (x = 0, 0.3, 0.6 and 1) and reducing agent (0.5, 2.5, 4.5 and 6.5 mmol), at various pH levels (9.5, 10.5 and 11.5). The concentration of reducing agent and pH had an effect on obtaining pure spherical magnetic NPs. Also, the amount of cobalt ion in CoxFe3-xO4 spinel ferrite had a significant effect on specific loss power (SLP) and intrinsic loss power (ILP). At an optimum level of cobalt content (x = 0.6), SLP and ILP values of 117.12 W/g and 9.86 nHm2/kg were achieved, respectively. The optimized NP was then coated using polyethylene glycol (PEG). In vitro cytotoxicity evaluations revealed the non-cytotoxic nature of PEG coated NPs. The optimized NPs with SLP and ILP values, higher than the commercial ferrofluids, can be an appropriate choice for magnetic hyperthermia application.Graphical abstract
Source: Physica E: Low dimensional Systems and Nanostructures - Category: Nanotechnology Source Type: research