Flavans and other chemical constituents of Crinum biflorum (Amaryllidaceae)

Publication date: December 2019Source: Biochemical Systematics and Ecology, Volume 87Author(s): Boris Y. Kianfé, Rémy B. Teponno, Jonas Kühlborn, Roland T. Tchuenguem, Beaudelaire K. Ponou, Soleiman E. Helaly, Jean P. Dzoyem, Till Opatz, Léon A. TapondjouAbstractThe ethyl acetate extract from the whole plant of Crinum biflorum Rottb. Showed a moderate activity against Enterococcus faecalis. Its phytochemical investigation led to the isolation of a new flavan-3-ol derivative namely (2R,3R)-3-hydroxy-7-methoxy-3′,4′-methylenedioxyflavan, together with (2S)-7-hydroxy-3′,4′-methylenedioxyflavan, (2R,3R)-7-methoxy-flavan-3-ol, (2S)-7-hydroxy-3′,4′-dimethoxyflavan, 3′,7-dihydroxy-4′-methoxyflavan, 4′,7-dimethoxy-3′-hydroxyflavan, farrerol, β-sitosterol, β-sitosterol-3-O-β-D-glucopyranoside, oleanolic acid, kaempferol, pancratistatin, lupeol, aurantiamide acetate, Narciprimine and 2,3-dihydroxypropyl palmitate. Their structures were elucidated mainly by extensive spectroscopic analysis and comparison with published data. The absolute configuration of the new metabolite was determined by electronic circular dichroism (ECD) analysis and comparison of optical rotation. Some of the isolated compounds were tested for their antimicrobial activity but no inhibition was observed.Graphical abstract
Source: Biochemical Systematics and Ecology - Category: Biochemistry Source Type: research