Diversification and CXCR4-Dependent Establishment of the Bone Marrow B-1a Cell Pool Governs Atheroprotective IgM Production Linked To Human Coronary Atherosclerosis.

Conclusions: These data provide the first report of a unique BM B-1a cell IgM repertoire and identifies CXCR4 expression as a critical factor selectively governing BM B-1a localization and anti-OSE IgM production. That CXCR4 expression on human B-1 cells was greater in humans with low coronary artery plaque burden suggests a potential targeted approach for immune modulation to limit atherosclerosis.
PMID: 31549940 [PubMed - as supplied by publisher]

Source: Circulation Research - September 23, 2019 Category: Cardiology Authors: Upadhye A, Srikakulapu P, Gonen A, Hendrikx S, Perry HM, Nguyen AT, McSkimming C, Marshall M, Garmey J, Taylor A, Bender TP, Tsimikas S, Holodick NE, Rothstein TL, Witztum JL, McNamara CA Tags: Circ Res Source Type: research