Modest and non-essential roles of the endocannabinoid system in immature hematopoiesis of mice

Hematopoiesis, i.e. the continuous, life-long process of generating short-lived mature blood cells, originates from hematopoietic stem and progenitor cells (HSPCs) [1], the proliferation of which is tightly controlled. The hematopoietic organ is physically located in the bone marrow (BM) where HSPCs interact in an intricate fashion with their environment, the niche [2]. Under the influence of the latter, HSPCs give rise to increasingly more differentiated precursors and mature blood cells which are ultimately released into the peripheral blood [3].

Source: Experimental Hematology - September 24, 2019 Category: Hematology Authors: Eva Danner, Frauke Hoffmann, Seo-Youn Lee, Fabian Cordes, Sabine Orban, Katrin Dauber, Doreen Chudziak, Gabriele Spohn, Eliza Wiercinska, Benjamin Tast, Darja Karpova, Halvard Bonig Source Type: research