Transforming growth factor- β receptor internationalization via caveolae is regulated by tubulin-β2 and tubulin-β3 during endothelial-mesenchymal transition.

This study is the first to demonstrate that glycosylation of tubulin-β2 (TUBB2) and tubulin-β3 (TUBB3) in microtubules enhances sensitivity to TGF-β1 stimulation in human microvascular endothelial cells. We observed that the microtubules enriched in glycosylated TUBB2 and TUBB3 were necessary for caveolae-dependent TGF-β receptor internalization. Posttranslational modulation is critical for the generation of myofibroblasts through endothelial-mesenchymal transition during fibrosis development. We suggest that microtubule glycosylation may become the target of new effective therapies for patients with recognized fibrotic diseases.
PMID: 31539520 [PubMed - as supplied by publisher]

Source: The American Journal of Pathology - September 16, 2019 Category: Pathology Authors: Sobierajska K, Wawro ME, Ciszewski WM, Niewiarowska J Tags: Am J Pathol Source Type: research